18060-37-2

Usage

Molecular Structure

Consists of a quinoline core with a carboxylic acid group, a trifluoromethyl group, and a methoxyphenyl group attached.

Quinoline Derivative

Exhibits various biological activities, such as antimicrobial, antimalarial, and anti-tumor properties.

Trifluoromethyl Group

Enhances the compound's chemical and physical properties, making it potentially useful in certain synthetic processes.

Upstream product

• 391-12-8 7-trifluoromethylisatin 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 148887-84-7 {[2-(4-Methoxy-phenyl)-8-trifluoromethyl-quinoline-4-carbothioyl]-methyl-amino}-acetic acid ethyl ester 
• 148887-71-2 {[2-(4-Methoxy-phenyl)-8-trifluoromethyl-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and aldose reductase inhibitory activity of N-(quinolinyl thiocarbonyl) glycine derivatives

The onset of diabetic complications may be prevented by the inhibition of aldose reductase.Derivatives of N-(quinolinyl thiocarbonyl) glycine were prepared and their in vitro and ex vivo aldose reductase inhibitory activities were tested on rat lens.The cincophen derivatives were the most potent in vitro with an enzyme inhibition value of 29percent at 10-8 M and 91percent at 10-7 for the N--N-methylglycine compound 10a.This activity was shown to be dependent on the nature of the substituents and seems to be optimal for the acids; esterswerefound to be inactive.No compound have shown ex vivo inhibitory activity.It is concluded that the lack of ex vivo activity is likely due to a poor bioavailability or a bad penetration of the compounds in target tissue (lens). aldose reductase inhibitors / diabetic complications / N-(quinolinyl thiocarbonyl) glycine