18060-72-5

Usage

Uses

Used in Agriculture:
3-methylsulfanyl-2H-1,2,4-triazin-5-one is used as a herbicide for controlling broadleaf and grassy weeds in various crops such as cotton, corn, and soybeans. It is effective in managing unwanted plant growth, thereby improving crop yield and quality.
Used in Environmental Regulation:
Due to its potential environmental impact, the use and application of 3-methylsulfanyl-2H-1,2,4-triazin-5-one are regulated in many countries. This ensures that it is used properly to minimize harm to aquatic organisms and bees, as well as to protect the overall ecosystem.

InChI:InChI=1/C4H5N3OS/c1-9-4-6-3(8)2-5-7-4/h2H,1H3,(H,6,7,8)

Upstream product

• 626-08-4 6-aza-2-thiouracil 
• 74-88-4 methyl iodide 

Downstream Products

• 6943-94-8 1-methyl-6-azauracil 
• 1384852-57-6 3-(methylthio)-6-(2-oxo-2-phenylethyl)-1,6-dihydro-1,2,4-triazin-5(4H)-one 

Relevant academic research and scientific papers

2-HYDROXYIMINOPYRIMIDINE NUCLEOSIDES AND DERIVITIVES AND ANTIVIRAL USES THERETO

Disclosed herein are nucleosides and nucleotides analogs, methods for preparing the same, and methods for treating and/or ameliorating infection caused by a Coronaviridae virus, a Caliciviridae virus, an Orthomyxoviridae virus, a Herpesviridae virus, a Flaviviridae virus, a Filoviridae virus,and a Pneumoviridae virus with one or more nucleoside and nucleotide analogs of formula I. In certain embodiments, compounds and compositions of nucleoside or nucleotide derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are according to Formula (I): or a pharmaceutically acceptable salt, solvate, stereoisomeric form, a tautomeric form or polymorphic form thereof, wherein R1, R2, R3, R4, X, and sugar are as described herein.

Regioselective synthesis of 1,2,4-triazin-5-one via gas-phase pyrolysis of 4-arylidenimino-3(2H)-thioxo-1,2,4-triazin-5(4H)-one. Kinetic and mechanistic study

4-Arylidenimino-3(2H)-thioxo-1,2,4-triazin-5(4H)-ones (1a-e) and 4-arylidenimino-3-methylthio-1,2,4-triazin-5(4H)-ones (2a-e) were synthesized. Pyrolytic deprotection of these substrates were carried out. The kinetic results, product analysis and theoretical studies lend support to a reaction pathway involving a six-membered transition state in which the carbonyl and not thione bond attacks the hydrogen atom of the arylidenimino group. This reaction represents an efficient, clean and general synthetic procedure for the protection and selective synthesis of potential biologically active triazines and their derivatives. Copyright

3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives as 5HT1A ligands

A 3,5-dioxo-(2H,4H)-1,2,4-triazine compounds of formula I STR1 in which: R1 and R2, which are identical or different, represent hydrogen or C1 -C6 alkyl, n is 2 to 6, inclusive, A represents aryl piperazino II STR2 the Ar grouping representing phenyl, naphthyl, pyrimidyl, or pyridyl, unsubstituted or substituted by C1 -C3 alkyl, C1 -C3 alkoxy, hydroxy, trifluoromethyl, or halogen, or III benzodioxanyl-methyl-amino or pyridodioxanyl-methyl-amino STR3 in which R represents hydrogen or C1 -C3 alkyl and X represents a nitrogen or carbon atom, therapeutically-acceptable salts and enantiomers thereof, pharmaceutical compositions thereof, and method for treatment of diseases requiring a 5HT1A receptor agonist therewith.