180609-04-5

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 188548-07-4 5-Oxo-2-phenethyl-pyrrolidine-2-carboxylic acid ethyl ester 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 180609-02-3 2-(Benzhydrylidene-amino)-2-phenethyl-pentanedioic acid diethyl ester 
• 170943-41-6 2-(Benzhydrylidene-amino)-4-phenyl-butyric acid ethyl ester 
• 17376-04-4 2-phenethyl iodide 

Downstream Products

• 188548-20-1 ethyl N-(tert-butoxycarbonyl)-2-(2-phenylethyl)-4-methylenepyroglutamate 

Relevant academic research and scientific papers

Ethyl N-(diphenylmethylene)glycinate as anionic glycine equivalent. Monoalkylation, dialkylation and michael additions under solid-liquid phase-transfer catalysis

Ethyl N-(diphenylmethylene)glycinate, 1, undergoes monoalkylations, dialkylations and Michael additions to ethylenic and acetylenic acceptors under appropriate solid-liquid phase transfer catalysis conditions. Further transformations of the α-disubstituted ketimines lead to α-alkylated aspartic and glutamic acid derivatives 10, 15, 19 and 26, to bicyclic amino acids or derivatives featuring pyrazolone and isoxazolone moieties 30 and 33, and to α-substituted (E)-3,4-dehydroglutamic acids. Copyright

Synthesis of 2-substituted 4methyleneglutamic acids and their cyclopropyl analogues

The alkylation of the dianion 10 derived from ethyl 4-methylenepyroglutamate (9) allows the synthesis of 2-substituted 4-methylenepyroglutamates 12, after final W-Boc protection. They can also be prepared by alkylation at the 2-position of dianion 14 deri