180609-35-2

Upstream product

• 3068-31-3 2,3,4-tri-O-acetyl-α-D-xylopyranosyl bromide 
• 180609-24-9 2,6,7,7a-tetrahydro-7a-methyl-3-(1-methylethyl)-5-trifluoromethylsulfonyl-oxy-1H-indene 
• 180609-25-0 3-Isopropyl-7a-methyl-2,6,7,7a-tetrahydro-1H-indene-5-carboxylic acid methyl ester 
• 16643-72-4 trans-3-isopropyl-7a-methyl-1,2,3,6,7,7a-hexahydroinden-5-one 
• 3068-31-3 1-bromo-2,3,4-tri-O-acetyl-α-D-xylopyranose 
• 180609-23-8 6-methyl-9-(1-methylathyl)bicyclo[4.3.0]nona-2,9-diene-3-carboaldehyde 
• 180609-26-1 2,6,7,7a-tetrahydro-5-hydroxymethyl-7a-methyl-3-(1-methylethyl)-1H-indene 

Relevant academic research and scientific papers

Synthesis of (±)-allocyathin B2 and (+)-erinacine A

(±)-Allocyathin B2 (2) and (+)-erinacine A (4), the 1-β-D-xyloside of (+)-allocyathin B2, the first cyathin diterpenes to be prepared, have been synthesized using a carbonyl ene reaction of 14a to construct an appropriately functionalized seven-membered ring and palladium-catalyzed carbonylation of dienyl triflates 10 and 39 as key steps. The entire cyathin carbon skeleton is constructed in seven steps, and allocyathin B2 is synthesized in only 17 steps (>5%overall yield) from readily available enone 9.