180611-35-2

Upstream product

• 160531-15-7 (S)-3-(benzyloxy)-4-methylpentanal 
• 180611-34-1 (S)-5-Benzyloxy-6-methyl-heptan-1-ol 

Downstream Products

• 180611-36-3 (4R,5S)-3-((2R,3S,7S)-7-Benzyloxy-3-hydroxy-2,8-dimethyl-nonanoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 180611-39-6 4-Nitro-benzoic acid (R)-1-isopropyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butyl ester 
• 180611-38-5 (4R,5S)-4-((S)-4-Benzyloxy-5-methyl-hexyl)-2,2,5-trimethyl-[1,3]dioxane 

Relevant academic research and scientific papers

Isolation and stereostructures of dolastatin G and nordolastatin G, cytotoxic 35-membered cyclodepsipeptides from the Japanese sea hare Dolabella auricularia

A bioassay-directed fractionation of the cytotoxic constituents of the Japanese sea hare Dolabella auricularia resulted in the isolation of two 35-membered depsipeptides dolastatin G (1) and nordolastatin G (2), which showed cytotoxicity against HeLa S3 cells with IC50 values of 1.0 and 5.3 μg/mL, respectively. The gross structures of these substances were established by spectroscopic analysis including 2D NMR techniques. The absolute stereostructure of 1 was determined by chiral HPLC analysis of amino acid components obtained from acid hydrolysis of 1 and by the enantioselective syntheses of two degradation products arising from polyketide portions. Nordolastatin G (2) is a congener that has the same absolute stereochemistry as that of 1.