180623-45-4

Basic information

• Product Name: 5-bromo-N-(2,4-dichlorophenyl)pentanamide
• Synonyms: 5-bromo-N-(2,4-dichlorophenyl)pentanamide
• CAS NO: 180623-45-4
• Molecular Weight: 325.032
• Mol File: 180623-45-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-bromo-N-(2,4-dichlorophenyl)pentanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-N-(2,4-dichlorophenyl)pentanamide(180623-45-4)
• EPA Substance Registry System: 5-bromo-N-(2,4-dichlorophenyl)pentanamide(180623-45-4)

Safety Data

• Hazardous Substances Data: 180623-45-4(Hazardous Substances Data)

Upstream product

• 4509-90-4 5-bromovaleroyl chloride 
• 554-00-7 2,4-Dichloroaniline 

Downstream Products

• 180622-79-1 Thioacetic acid S-[5-(2,4-dichloro-phenylamino)-pentyl] ester 
• 180623-46-5 1-bromo-5-(2,4-dichloroanilino)pentane 

Relevant articles and documents

Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization

Interleukin (IL)-15 is a pleiotropic cytokine, which is structurally close to IL-2 and shares with it the IL-2 β and γ receptor (R) subunits. By promoting the activation and proliferation of NK, NK-T, and CD8+ T cells, IL-15 plays important roles in innate and adaptative immunity. Moreover, the association of high levels of IL-15 expression with inflammatory and autoimmune diseases has led to the development of various antagonistic approaches targeting IL-15. This study is an original approach aimed at discovering small-molecule inhibitors impeding IL-15/IL-15R interaction. A pharmacophore and docking-based virtual screening of compound libraries led to the selection of 240 high-scoring compounds, 36 of which were found to bind IL-15, to inhibit the binding of IL-15 to the IL-2Rβ chain or the proliferation of IL-15-dependent cells or both. One of them was selected as a hit and optimized by a structure-activity relationship approach, leading to the first small-molecule IL-15 inhibitor with sub-micromolar activity.