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180628-74-4

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180628-74-4 Usage

General Description

3-Hydroxy-5-nitro-benzenemethanol, also known as Nitrobenzyl alcohol, is a chemical compound that belongs to the class of benzyl alcohols. It is a pale yellow to red crystalline solid that is often used as a pharmaceutical intermediate in the synthesis of various drugs, and as a reagent in organic chemistry. Benzenemethanol, 3-hydroxy-5-nitro- is known for its nitro group, which makes it suitable for use in the production of nitrocellulose, a highly flammable compound used in explosives and lacquers. Additionally, 3-Hydroxy-5-nitro-benzenemethanol has been studied for its potential use in the treatment of microbial infections due to its antibacterial properties. However, it is important to handle this chemical with caution as it can be harmful if ingested or inhaled, and may cause skin and eye irritation upon contact.

Check Digit Verification of cas no

The CAS Registry Mumber 180628-74-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,6,2 and 8 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 180628-74:
(8*1)+(7*8)+(6*0)+(5*6)+(4*2)+(3*8)+(2*7)+(1*4)=144
144 % 10 = 4
So 180628-74-4 is a valid CAS Registry Number.

180628-74-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(Hydroxymethyl)-5-nitrophenol

1.2 Other means of identification

Product number -
Other names 3-hydroxy-5-nitrobenzyl alcohol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:180628-74-4 SDS

180628-74-4Downstream Products

180628-74-4Relevant articles and documents

Linker Hydrophilicity Modulates the Anticancer Activity of RGD–Cryptophycin Conjugates

Anselmi, Michele,Borbély, Adina,Figueras, Eduard,Michalek, Carmela,Kemker, Isabell,Gentilucci, Luca,Sewald, Norbert

supporting information, p. 1015 - 1022 (2020/12/11)

Most anticancer agents are hydrophobic and can easily penetrate the tumor cell membrane by passive diffusion. This may impede the development of highly effective and tumor-selective treatment options. A hydrophilic β-glucuronidase-cleavable linker was used to connect the highly potent antimitotic agent cryptophycin-55 glycinate with the αvβ3 integrin ligand c(RGDfK). Incorporation of the self-immolative linker containing glucuronic acid results in lower cytotoxicity than that of the free payload, suggesting that hydrophilic sugar linkers can preclude passive cellular uptake. In vitro drug-release studies and cytotoxicity assays demonstrated the potential of this small molecule–drug conjugate, providing guidance for the development of therapeutics containing hydrophobic anticancer drugs.

Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis

Hartung, Ingo V.,Rude, Mathew A.,Schnarr, Nathan A.,Hunziker, Daniel,Khosla, Chaitan

, p. 11202 - 11203 (2007/10/03)

Natural and semisynthetic rifamycins are clinically important inhibitors of bacterial DNA-dependent RNA polymerase. Although the polyketide-nonribosomal peptide origin of the naphthalene core of rifamycin B is well established, the absolute and relative c

Total synthesis of (+)-trienomycins A and F

Smith III,Smith III, Amos B.,Barbosa,Barbosa, Joseph,Wong,Wong, Weichyun,Wood,Wood, John L.

, p. 10777 - 10778 (2007/10/03)

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