180628-74-4

Usage

Uses

Used in Pharmaceutical Industry:
Benzenemethanol, 3-hydroxy-5-nitro-, is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure allows it to be a key component in the development of new medications.
Used in Organic Chemistry:
Benzenemethanol, 3-hydroxy-5-nitro-, is used as a reagent in organic chemistry. Its nitro group makes it a versatile compound for various chemical reactions and synthesis processes.
Used in Production of Nitrocellulose:
Benzenemethanol, 3-hydroxy-5-nitro-, is used in the production of nitrocellulose, a highly flammable compound used in explosives and lacquers. Its nitro group contributes to the compound's properties, making it suitable for these applications.
Used in Treatment of Microbial Infections:
Benzenemethanol, 3-hydroxy-5-nitro-, has been studied for its potential use in the treatment of microbial infections due to its antibacterial properties. Its ability to target and eliminate bacteria makes it a promising candidate for antimicrobial applications.
However, it is important to handle Benzenemethanol, 3-hydroxy-5-nitro-, with caution as it can be harmful if ingested or inhaled, and may cause skin and eye irritation upon contact. Proper safety measures should be taken during its use to minimize potential risks.

Upstream product

• 78238-12-7 3-methoxy-5-nitrobenzoic acid 
• 99-34-3 3,5-dinitrobenzoic acid 
• 78238-14-9 3-hydroxy-5-nitrobenzoic acid 

Downstream Products

• 180628-75-5 3-Bromomethyl-5-nitro-phenol 

Relevant academic research and scientific papers

Linker Hydrophilicity Modulates the Anticancer Activity of RGD–Cryptophycin Conjugates

Most anticancer agents are hydrophobic and can easily penetrate the tumor cell membrane by passive diffusion. This may impede the development of highly effective and tumor-selective treatment options. A hydrophilic β-glucuronidase-cleavable linker was used to connect the highly potent antimitotic agent cryptophycin-55 glycinate with the αvβ3 integrin ligand c(RGDfK). Incorporation of the self-immolative linker containing glucuronic acid results in lower cytotoxicity than that of the free payload, suggesting that hydrophilic sugar linkers can preclude passive cellular uptake. In vitro drug-release studies and cytotoxicity assays demonstrated the potential of this small molecule–drug conjugate, providing guidance for the development of therapeutics containing hydrophobic anticancer drugs.

Synthesis of an Advanced Fragment of (+)-Trienomycinol

The synthesis of the fully functionalized eastern fragment of trienomycins A-F, ansamycin antibiotics is described. A key step involves a peptidic coupling between a sulfonyl aniline and an enantiopure carboxylic acid obtained by a completely diastereosel

Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis

Natural and semisynthetic rifamycins are clinically important inhibitors of bacterial DNA-dependent RNA polymerase. Although the polyketide-nonribosomal peptide origin of the naphthalene core of rifamycin B is well established, the absolute and relative c

Total syntheses of (+)-trienomycins A and F via a unified strategy

The first total syntheses of (+)-trienomycins A and F, representative members of a new class of cytotoxic ansamycin antibiotics, have been achieved. Key features of the unified synthetic scheme included incorporation of the (E,E,E)-triene unit with concom