180633-76-5

Upstream product

• 180633-60-7 (1-benzenesulfonyl-6-benzyloxy-1H-indol-3-yl)-(1-benzyloxymethyl-4-iodo-1H-imidazol-2-yl)-methanol 
• 180633-62-9 (1-benzenesulfonyl-6-benzyloxy-1H-indol-3-yl)-(1-benzyloxymethyl-4-iodo-1H-imidazol-2-yl)-methanone 
• 180633-56-1 1-benzenesulfonyl-6-benzyloxy-1H-indole-3-carboxaldehyde 
• 134420-43-2 1-benzyloxymethyl-4,5-diiodo-1H-imidazole 
• 180633-64-1 (1-benzenesulfonyl-6-benzyloxy-1H-indol-3-yl)-[4-(1-benzenesulfonyl-1H-indol-3-yl)-1-benzyloxymethyl-1H-imidazol-2-yl]-methanone 

Downstream Products

• 112515-43-2 topsentin 

Relevant academic research and scientific papers

Convenient access to bis-indole alkaloids. Application to the synthesis of?topsentins

Topsentins and related bis-indole alkaloids may be efficiently synthesized through an addition/oxidation sequence leading to 2-(3-indolylcarbonyl)-imidazole derivatives followed by a Pd-catalyzed heteroarylation with the appropriate 3-stannylindoles.

A three-component coupling approach to the marine bis-indole alkaloids: Topsentin, deoxytopsentin and bromotopsentin

The total syntheses of three marine bis-indole alkaloids (1, 2, 4) of the topsentin family together with the synthesis of unnatural deoxybromotopsentin (33) are described. Key elements include, a 1,2-addition-oxidation sequence to construct the bis-hetero