180676-86-2Relevant academic research and scientific papers
1,4-Dihydropyridazines, furanes and pyrroles with unlike ester groups related to nifedipine
Goerlitzer,Behrje
, p. 523 - 527 (2007/10/03)
The 2,3-dihydro-2-hydroxyfuranes 4 are obtained from the 1,3-dithiolanes 3 by oxidative cleavage. Heating in acetic acid the enole half ketales 4 react with hydrazine to yield the 1,4-dihydropyridazines 6 and as by-products the N-aminopyrroles 7 and 8. From 4a and hydroxylamine the N-hydroxypyrrole 10 is formed, with methylamine the N-methylpyrrole 11 is received. On the other hand the half aminales 12 are isolated from 4 and ammonium acetate using ethanol as solvent. The compounds 4 and 12 can be easily dehydrated to give the furanes 14 and the pyrroles 15.
