180680-59-5

Upstream product

• 2706-56-1 2-(aminoethyl)pyridine 
• 2973-19-5 2-hydroxy-5-nitrobenzyl chloride 
• 101079-17-8 N-(pyridine-2-ylethyl)-2-hydroxy-5-nitro-benzylideneamine 

Relevant academic research and scientific papers

A series of mononuclear Co(III) complexes using tridentate N,O-donor ligands: Chemical properties and cytotoxicity activity

Continuing our interest in tridentate ligands to develop new prototypes of cobalt-based metallodrugs for combating cancer, modifications in the backbone of HL1, [(2-hydroxybenzyl)(2-(pyridil-2-yl)ethyl]amine) were proposed in order to modulate the redox potential of new Co(III) complexes. Three ligands with electron withdrawing groups were synthesized: HL2: [(2-hydroxy-5-nitrobenzyl)(2- (pyridil-2-yl)ethyl]amine); HL3: [(2-hydroxybenzyl)(2-(pyridil-2-yl)ethyl]imine) and HL4: [(2-hydroxy-5-nitrobenzyl)(2-(pyridil-2-yl)ethyl]imine). They were used to obtain the respective mononuclear complexes 2, 3 and 4, which are discussed compared to the previous reported complex 1 (obtained from HL1). The new complexes were characterized and studied by several techniques including X-ray crystallography, elemental and conductimetric analysis, IR, UV-vis and 1H NMR spectroscopies, and electrochemistry. The substitutions of the group in the para position of the phenol (HL1 and HL2) and the imine instead of the amine (HL3 and HL4), promote anodic shifts in the complexes reduction potentials. The influence of these substitutions in the biological activities of the Co(III) complexes against the murine melanoma cell line (B16F10) was also evaluated. Little effect was observed on cellular viability decrease for all free ligands, however the coordination to Co(III) enhances their activities in the following range: 1 > 4 ≈ 2 > 3. The data suggest that no straight correlation can be addressed between the reduction potential of the Co(III) center and the cell viability.

Synthesis, structure, spectra and redox chemistry of iron(III) complexes of tridentate pyridyl and benzimidazolyl ligands

A series of high-spin octahedral 1:2 iron(III) complexes of Schiff bases derived from salicylaldehyde and aromatic amines and the 1:1 and 1:2 complexes of bis(pyridin-2-yl)-aza and bis(benzimidazol-2-yl)-aza and -thioether ligands have been isolated. The

Zinc(II) complexes of tripodal ligands providing phenolate and pyridine donors: Formation, structure and hydrolytic activity

A group of zinc(II) complexes derived from tri- and tetra-dentate proligands bearing pyridyl and phenolic arms have been prepared and characterised. Potentiometric titrations suggested that a stepwise complexation initially to the pendant OH, and then to pendant O- occurred. The crystal structures of [Zn2L32][ClO4]2 (L3 = 2-{bis[2-(2-pyridyl)ethyl]aminomethyl}phenolate) and [Zn2L62][Zn(NCS)4]·0.5H 2O (L6 = 2-{bis[2-(2-pyridyl)ethyl]aminomethyl}-4-nitrophenolate) reveal that both complexes are dimers in the solid state; the co-ordination geometries around zinc(II) can be best described as distorted square pyramidal with one pyridyl nitrogen atom, one tertiary nitrogen atom and two phenolic oxygen atoms forming the basal plane and a pyridyl nitrogen atom in the axial position. The interzinc separations are 3.284 A and 3.274 A respectively. The crystal structure of [Zn L72] (L7 = 4-nitro-2-{[2-(2-pyridyl)ethyl]aminomethyl}phenolate) reveals an octahedral complex with the zinc atom on a symmetry centre. The complexes [Zn2L32][ClO4]2 and [Zn2L62][BPh4]2, promote the hydrolysis of tris(4-nitrophenyl) phosphate; the former also has a small activity in the hydrolysis of bis(4-nitrophenyl) phosphate.