180693-08-7Relevant academic research and scientific papers
Unusual cytotoxicities of 5-(acylethynyl)-1-(2- hydroxyethoxy)methyluracils
Kundu, Nitya G.,Mahanty, Jyan S.,Spears, C. Paul
, p. 1497 - 1502 (2007/10/03)
5-(Acylethynyl)-1-(2-hydroxyethoxy)methyl uracils (2)-(6) were synthesised in excellent yields from 1-(2-acetoxyethoxy)methyl-5-iodouracil (7) utilising palladium-copper catalysed reactions. Compounds (2)-(5) were shown to be highly active against CCRF-CEM (IC50 0.6-1.6 μM) and L1210/0 cells (IC50 0.7-2.2 μM) in culture, and thus exhibit greater activity than their parent bases.
