1807-49-4

Basic information

• Product Name: (1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)diazenium
• CAS NO: 1807-49-4
• Molecular Formula: C₉H₄N₂O₂
• Molecular Weight: 173.1477
• Mol File: 1807-49-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)diazenium(CAS DataBase Reference)
• NIST Chemistry Reference: (1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)diazenium(1807-49-4)
• EPA Substance Registry System: (1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)diazenium(1807-49-4)

Safety Data

• Hazardous Substances Data: 1807-49-4(Hazardous Substances Data)

Usage

General Description

(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)diazenium is a chemical compound that belongs to the class of diazeniumdiolates. It is a stable and potent nitric oxide (NO) donor, which releases NO upon decomposition in aqueous solution. NO plays a crucial role in various physiological processes, including vasodilation, neurotransmission, and immune response. Therefore, (1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)diazenium has potential applications in therapeutics for conditions such as hypertension, pulmonary hypertension, and ischemia-reperfusion injury. Its ability to release NO in a controlled manner makes it a promising candidate for the development of NO-based pharmaceuticals with enhanced efficacy and reduced side effects. Further research and studies are needed to explore its full potential and possible applications in the field of medicine.

Upstream product

• 35662-09-0 2-phenylsulfanyl-2,3-dihydro-1H-indane-1,3-dione 
• 606-23-5 1H-indene-1,3(2H)-dione 
• 78350-49-9 4-azido-1,2,5-oxadiazol-3-amine 
• 85-44-9 phthalic anhydride 

Downstream Products

• 105678-94-2 2-phenylspiroindene>-1',3'-dione 
• 114158-24-6 2-(4-chlorophenyl)spiroindene>-1',3'-dione 
• 114158-26-8 2-(4-nitrophenyl)spiroindene>-1',3'-dione 
• 114158-25-7 2-(4-bromophenyl)spiroindene>-1',3'-dione 
• 114158-17-7 2-cyclohexylindan-1,3-dione 
• 113138-74-2 2-(1,1-Dimethyl-allyl)-2-phenylsulfanyl-indan-1,3-dione 
• 117-37-3 anisindione 
• 1146-99-2 clorindione 
• 1470-42-4 2-(2-chlorophenyl)-1,3-dioxoindane 
• 15432-97-0 2-(2-methylphenyl)-1,3-dioxoindane 
• 7561-48-0 2-(4-methylphenyl)indan-1,3-dione 
• 114158-19-9 2-(3-cyclohexenyl)-1,3-indandione 
• 114158-18-8 spiroheptane-7,2'-<2H>indene>-1',3'-dione 
• 83-12-5 phenindione 

Relevant articles and documents

Azido-1,2,5-oxadiazoles in reactions with 1,3-dicarbonyl compounds

The 1,3-dipolar cycloaddition of azido-1,2,5-oxadiazoles (azidofurazans) to dicarbonyl compounds was studied, and a new procedure for the synthesis of 4-R-3-(4-R1-5-R2-1,2,3-triazol-1-yl)-1,2,5-oxadiazoles was proposed.

Reactions of tosyl azide with 2-phenoxy- and 2-phenylsulfanyl-2,3-dihydro-1H-indane-1m3-dione. Unexpected reactivity of intermediate 4-acyl-5-hydroxy-1-tosyltriazolenes

The reaction of tosyl azide 1 with 2-phenoxy-2,3-dihydro-1H-indane-1,3-dione 2c, carried out in hexamethylphosphoramide (HMPA) or in diethyl ether in the presence of triethylamine, fails to afford the expected diazo transfer product, i.e. the diazoacetophenone 3c (3c'), but instead leads to the dimeric indanedione 7 the formation of which is primarily ascribable to preferential fragmentation of the transient hydroxytriazoline 4c to give zwitterion 9c and dinitrogen.Under comparable conditions, tosyl azide 1 and 2-phenylsulfanyl-2,3-dihydro-1H-indane-1,3-dione 2d in HMPA gives the ring-expanded hydroxybenzopyran 15, the formation of which is similarly ascribed to preferential fragmentation of the corresponding 4,5-dihydro-1H-triazole 4d to give zwitterion 9d.However, analogous reaction of the dione 2d in THF, in the presence of triethylamine, affords 2-diazo-2,3-dihydro-1H-indane-1,3-dione along with diphenyl disulfide, toluene-p-sulfonamide and phenyl toluene-4-thiosulfonate.These latter products are believed to arise from ready decomposition of the 4,5-dihydro-1H-triazole 4d precursor, i.e. the triazenyl anion 13.X-Ray structure analyses of compound 7 and the acetoxybenzopyran 17 are also reported.