18073-15-9

Usage

Uses

Used in Organic Electronics:
6-Methoxy-1,4-dimethyl-9H-carbazole-3-carbaldehyde is used as a chemical intermediate for the synthesis of organic compounds in the field of organic electronics. Its unique structure and properties contribute to the development of advanced materials for applications such as organic light-emitting diodes (OLEDs) and organic semiconductors, enhancing their performance and efficiency.
Used in Medicinal Chemistry:
In the realm of medicinal chemistry, 6-Methoxy-1,4-dimethyl-9H-carbazole-3-carbaldehyde is utilized for its potential biological activity. Researchers have investigated its properties to explore its use in the development of new pharmaceutical compounds, leveraging its chemical structure to target specific biological pathways and mechanisms.
Used in Chemical Synthesis:
6-Methoxy-1,4-dimethyl-9H-carbazole-3-carbaldehyde serves as a key intermediate in the synthesis of a variety of organic compounds. Its presence in the molecular structure allows for the creation of new compounds with diverse applications across different industries, showcasing its importance in chemical research and development.

InChI:InChI=1/C16H15NO2/c1-9-6-11(8-18)10(2)15-13-7-12(19-3)4-5-14(13)17-16(9)15/h4-8,17H,1-3H3

Upstream product

• 18028-57-4 6-methoxy-1,4-dimethyl-9H-carbazole 
• 93-61-8 N-methyl-N-phenylformamide 
• 68-12-2 N,N-dimethyl-formamide 
• 1006-94-6 5-methoxylindole 

Downstream Products

• 120105-77-3 [2-Benzyloxy-eth-(E)-ylidene]-(6-methoxy-1,4-dimethyl-9H-carbazol-3-ylmethyl)-amine 
• 18073-24-0 dimethyl-1,4 (diethoxy-2,2 ethyliminomethyl)-3 methoxy-6 carbazole 
• 726181-22-2 6-methoxy-1,4-dimethyl-9H-carbazol-3-ol 
• 120105-76-2 (2-Benzyloxy-ethyl)-(6-methoxy-1,4-dimethyl-9H-carbazol-3-ylmethyl)-amine 
• 120105-78-4 3--6-methoxy-1,4-dimethylcarbazole 
• 120105-72-8 methyl 3,3-dimethoxy-2-<(6-methoxy-1,4-dimethylcarbazol-3-yl)methyl(4-tosyl)amino>propionate 
• 10371-86-5 9-methoxyellipticine 
• 18073-32-0 9-Methoxy-5,6,11-trimethyl-6H-pyrido<4,3-b>carbazol 
• 129117-54-0 3-amino-1,4-dimethyl-6-methoxy-9H-carbazole 
• 130005-62-8 3-amino-1,4-dimethyl-6-hydroxy-9H-carbazole 
• 103771-54-6 (+/-)-4-hydroxy-9-methoxy-1,2,3,4-tetrahydroellipticine 

Relevant academic research and scientific papers

Simple method for preparing ellipticine or substituted ellipticine

The invention relates to a synthesis process for preparing ellipticine. Ellipticine is obtained through six steps of reaction and three steps of crystallization separation, the target product total yield is high, column chromatography separation is not needed for an intermediate product and the target product, and the method is particularly suitable for large-scale preparation.

Design, synthesis, DNA binding studies and evaluation of anticancer potential of novel substituted biscarbazole derivatives against human glioma U87 MG cell line

In this research paper, we report the design and synthesis of novel substituted biscarbazole derivatives which were characterized by 1H and 13C NMR, high resolution mass spectroscopy (HRMS). The SAR study of the compounds is reported

Modifications to the Vilsmeier-Haack formylation of 1,4-dimethylcarbazole and its application to the synthesis of ellipticines

Figure represented. An improved method for the preparation of 3-formyl-1,4-dimethylcarbazole, a key intermediate in the synthesis of ellipticine, is presented. Conditions of the Vilsmeier-Haack reaction have been modified to facilitate the production of 3-formyl-1,4-dimethylcarbazole as a major product leading to an overall improvement in yield of ellipticine from 3% to 14%. This approach was also applied to the synthesis of 6-methylellipticine and 9-methoxyellipticine.

Ellipticines and 9-acridinylamines as inhibitors of d-alanine:d-alanine ligase

d-Alanine:d-alanine ligase (Ddl), an intracellular bacterial enzyme essential for cell wall biosynthesis, is an attractive target for development of novel antimicrobial drugs. This study focused on an extensive evaluation of two families of Ddl inhibitors encountered in our previous research. New members of both families were obtained through similarity search and synthesis. Ellipticines and 9-acridinylamines were both found to possess inhibitory activity against Ddl from Escherichia coli and antimicrobial activity against E. coli and Staphylococcus aureus. Ellipticines with a quaternary methylpyridinium moiety were the most potent among all studied compounds, with MIC values as low as 2 mg/L in strains with intact efflux mechanisms. Antimicrobial activity of the studied compounds was connected to membrane damage, making their development as antibacterial drug candidates unlikely unless analogues devoid of this nonspecific effect can be discovered.