180736-80-5

Upstream product

• 180736-86-1 1-hydroxy-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-1,4-dien-3-one 
• 85458-25-9 5,5-dimethoxy-1-(2,6,6-trimethyl-cyclohex-1-enyl)-pent-1-en-3-one 
• 79-77-6 (E)-β-ionone 
• 180736-79-2 2-[3-(2,2-dimethoxy-ethyl)-buta-1,3-dienyl]-1,3,3-trimethylcyclohexene 

Downstream Products

• 259181-78-7 2-[(2E,4E,6E)-1,5-Dimethyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trien-(E)-ylidene]-malonic acid monomethyl ester 
• 304466-91-9 (3E,7E)-6-Methylene-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-3,7-dien-2-one 
• 5560-99-6 (2X,4E)-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienal 
• 868773-11-9 (2E,4E,8E)-2-Methyl-7-methylene-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,8-trienoic acid ethyl ester 
• 379669-30-4 7-methylene-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,8-trienoic acid methyl ester 
• 379669-31-5 7-methylene-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,8-trien-1-ol 
• 20013-34-7 acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique 
• 302-79-4 all-trans-retinoic-acid 
• 4759-48-2 13-cis-retinoic acid 
• 868773-12-0 (2E,4E,8E)-2-Methyl-7-methylene-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,8-trien-1-ol 

Relevant academic research and scientific papers

Stereoselective synthesis of 9-methylene-13-demethyl analogs of natural retinoids

9-Methylene-13-demethyl analogs of retinol, retinal and retinoic acid, methyl ester were synthesised via new synthons β-methylenealdehydes.

Stereoselective syntheses of 13E and 13Z retinoic acids via a new intermediate C-15 β-methylenealdehyde

The methylene-de-oxo-bisubstitution reaction between dimethyl isopropylidene malonate and the C-15 β-methylenealdehyde 1 which could serve as substitute for E β-ionylideneacetaldehyde 2, produces stereoselectively the E,E olefin. Hence, new stereoselective syntheses of 13 E and 13 Z retinoic acids were described. (C) 2000 Elsevier Science Ltd.

Syntheses of new 9- and 13-methylene isomers of retinal

Syntheses of new 9- and 13-methylene isomers of retinal via the '9-methylene-C-18 ketone' 1 or 'C-18 ketone' 2 are reported. (C) 2000 Published by Elsevier Science Ltd.

Stereoselective synthesis of 13Z retinoic acids via β-methylenealdehydes as synthons

A stereoselective synthesis of 13Z retinoic acids via β-methylenealdehydes is described. In methylene-de-oxo-bisubstitution reactions (Knoevenagel, Stobbe, etc.), these new synthons produce stereoselectively E olefins. Hence, a synthesis of 13Z retinoic acids is described, via a stereospecific monodecarboxylation of carboxy-14-retinoic acids.