180736-84-9

Upstream product

• 180736-82-7 (E)-5,5-Dimethoxy-1-(2,6,6-trimethyl-cyclohex-2-enyl)-pent-1-en-3-one 
• 127-41-3 alpha-ionone 
• 230630-57-6 1-hydroxy-5-(2,6,6-trimethyl-cyclohex-2-enyl)-penta-1,4-dien-3-one 
• 180736-83-8 6-((E)-5,5-Dimethoxy-3-methylene-pent-1-enyl)-1,5,5-trimethyl-cyclohexene 

Downstream Products

• 379669-34-8 7-methylene-9-(2,6,6-trimethyl-cyclohex-2-enyl)-nona-2,4,8-trienoic acid methyl ester 
• 379669-35-9 7-methylene-9-(2,6,6-trimethyl-cyclohex-2-enyl)-nona-2,4,8-trien-1-ol 
• 180736-85-0 2-[(2E,4E,6E)-1,5-Dimethyl-7-(2,6,6-trimethyl-cyclohex-2-enyl)-hepta-2,4,6-trienylidene]-malonic acid 
• 58526-49-1 (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-2-enyl)nona-2,4,6,8-tetraenoic acid 

Relevant academic research and scientific papers

Stereoselective synthesis of 9-methylene-13-demethyl analogs of natural retinoids

9-Methylene-13-demethyl analogs of retinol, retinal and retinoic acid, methyl ester were synthesised via new synthons β-methylenealdehydes.

Stereoselective synthesis of 13Z retinoic acids via β-methylenealdehydes as synthons

A stereoselective synthesis of 13Z retinoic acids via β-methylenealdehydes is described. In methylene-de-oxo-bisubstitution reactions (Knoevenagel, Stobbe, etc.), these new synthons produce stereoselectively E olefins. Hence, a synthesis of 13Z retinoic acids is described, via a stereospecific monodecarboxylation of carboxy-14-retinoic acids.