180747-69-7Relevant academic research and scientific papers
Synthesis and chemical reactions of α-cyano-α-isocyanoalkanoic acids
Bergemann, Marco,Neidlein, Richard
, p. 975 - 980 (2007/10/03)
α-Cyano-α-isocyanoalkanoic acid esters 5 were synthesized in very good yields starting from alkyl α-cyano-α-(formylamido)acetates 3 by alkylation of the appropriate enolates followed by dehydration with trichloromethylchloroformate (diphosgene)/triethylamine at low temperatures. Bromination of these esters gave α-cyano-α-(dibromomethylideneamino)alkanoic acid esters 6 in quantitative yields. Reduction of 6 with magnesium led to 5.
