1807505-26-5

Basic information

• Product Name: Acid-PEG3-mono-methyl ester
• Synonyms: Acid-PEG3-mono-methyl ester;CARBOXY-PEG3-MONO-METHYL ESTER
• CAS NO: 1807505-26-5
• Molecular Formula: C11H20O7
• Molecular Weight: 264.2723
• Mol File: 1807505-26-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 396.7±32.0 °C(Predicted)
• Appearance: /
• Density: 1.162±0.06 g/cm3(Predicted)
• PKA: 4.27±0.10(Predicted)
• CAS DataBase Reference: Acid-PEG3-mono-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acid-PEG3-mono-methyl ester(1807505-26-5)
• EPA Substance Registry System: Acid-PEG3-mono-methyl ester(1807505-26-5)

Safety Data

• Hazardous Substances Data: 1807505-26-5(Hazardous Substances Data)

Usage

Description

Acid-PEG3-mono-methyl ester is a PEG (polyethylene glycol) linker that features a carboxylic acid and a methyl ester group. This molecule is designed to enhance the water solubility of compounds in aqueous media due to its hydrophilic PEG linker. The carboxylic acid group can participate in chemical reactions with primary amines to form stable amide bonds, facilitated by coupling agents such as EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide) and HATU (1-(6-Hexahydro-1H-azepin-1-yl)-1H-1,2,3-triazole-4-carboxamidine). Additionally, the methyl ester group is susceptible to hydrolysis under strong basic conditions, which can be exploited for various applications.

Uses

Used in Pharmaceutical Industry:
Acid-PEG3-mono-methyl ester is used as a molecular linker for enhancing the solubility and stability of therapeutic agents. Its ability to form stable amide bonds with primary amines allows for the creation of conjugates with improved pharmacokinetic properties, such as longer circulation times and reduced immunogenicity.
Used in Drug Delivery Systems:
In the field of drug delivery, Acid-PEG3-mono-methyl ester serves as a versatile component in the design of targeted drug carriers. The hydrophilic PEG linker can improve the biocompatibility and reduce the clearance rate of drug carriers, while the carboxylic acid group enables covalent attachment of therapeutic molecules or targeting ligands to the carrier system.
Used in Chemical Synthesis:
Acid-PEG3-mono-methyl ester is used as a building block in the synthesis of complex molecules, such as peptides, proteins, and other bioconjugates. The carboxylic acid and methyl ester functionalities provide multiple points of attachment and reactivity, allowing for the creation of diverse molecular structures with tailored properties.
Used in Diagnostics:
In the diagnostics industry, Acid-PEG3-mono-methyl ester can be employed to improve the solubility and stability of diagnostic agents, such as imaging contrast agents or molecular probes. The PEG linker can enhance the bioavailability and circulation time of these agents, while the carboxylic acid group can be used to attach specific targeting moieties for increased specificity and sensitivity in diagnostic applications.