Acid-PEG6-mono-methyl ester is a PEG (polyethylene glycol) linker that features a terminal carboxylic acid and a methyl ester group. This molecule is designed to enhance the water solubility of compounds in aqueous media, with the PEG chain's hydrophilic properties being more pronounced with longer PEG chains. The carboxylic acid group can react with primary amine groups in the presence of specific activators, such as EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide) and HATU (1-(6-((6-((2-Oxo-1,3-dioxo-1,3-diazepan-5-yl)methyl)amino)hexyl)oxy)-6-oxohexyl)-1,3-diazepan-5-ium-2-one), to form stable amide bonds, which is a crucial aspect for various applications in the pharmaceutical and chemical industries.
1807512-38-4
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Basic information
- Product Name: Acid-PEG6-mono-methyl ester
- Synonyms: Acid-PEG6-mono-methyl ester
- CAS NO:1807512-38-4
- Molecular Formula: C17H32O10
- Molecular Weight: 396.42998
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1807512-38-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in Water, DMSO, DCM, DMF
- CAS DataBase Reference: Acid-PEG6-mono-methyl ester(CAS DataBase Reference)
- NIST Chemistry Reference: Acid-PEG6-mono-methyl ester(1807512-38-4)
- EPA Substance Registry System: Acid-PEG6-mono-methyl ester(1807512-38-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1807512-38-4(Hazardous Substances Data)
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1807512-38-4 Usage
Uses
Used in Pharmaceutical Industry:Acid-PEG6-mono-methyl ester is used as a solubility enhancer for improving the aqueous solubility of hydrophobic drugs. The increased solubility can lead to better bioavailability and therapeutic efficacy of the drug.
Acid-PEG6-mono-methyl ester is also used as a conjugation agent for attaching drugs or targeting molecules to PEG chains. This conjugation can improve the pharmacokinetic properties of the drug, such as circulation time and stability in the body, as well as provide a means for targeted drug delivery.
Used in Chemical Synthesis:
In the field of chemical synthesis, Acid-PEG6-mono-methyl ester serves as a versatile building block for the creation of PEGylated compounds. The ability to form stable amide bonds with primary amine groups allows for the development of a wide range of PEGylated products with tailored properties and applications.
Used in Drug Delivery Systems:
Acid-PEG6-mono-methyl ester is used as a component in the design of drug delivery systems, where it can help in the formation of stable and biocompatible PEGylated nanoparticles or other carriers. These systems can improve the delivery, bioavailability, and therapeutic outcomes of various drugs, particularly for cancer treatments and other diseases where enhanced solubility and targeted delivery are beneficial.
Check Digit Verification of cas no
The CAS Registry Mumber 1807512-38-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,7,5,1 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.Calculate Digit Verification of CAS Registry Number 1807512-38:
(9*1)+(8*8)+(7*0)+(6*7)+(5*5)+(4*1)+(3*2)+(2*3)+(1*8)=164
164 % 10 = 4
So 1807512-38-4 is a valid CAS Registry Number.
1807512-38-4Upstream product
1807512-38-4Downstream Products
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Acid-PEG6-mono-methyl ester
