1807512-46-4

Basic information

• Product Name: Mal-PEG5-PFP
• Synonyms: Mal-PEG5-PFP
• CAS NO: 1807512-46-4
• Molecular Formula: C23H26F5NO9
• Molecular Weight: 555.445856
• Mol File: 1807512-46-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 594.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.376±0.06 g/cm3(Predicted)
• PKA: -2.34±0.20(Predicted)
• CAS DataBase Reference: Mal-PEG5-PFP(CAS DataBase Reference)
• NIST Chemistry Reference: Mal-PEG5-PFP(1807512-46-4)
• EPA Substance Registry System: Mal-PEG5-PFP(1807512-46-4)

Safety Data

• Hazardous Substances Data: 1807512-46-4(Hazardous Substances Data)

Usage

Description

Mal-PEG5-PFP is a PEG (polyethylene glycol) linker that contains maleimide and PFP (pentafluorophenyl) moieties. The maleimide group is thiol-reactive and can form thiolester bonds within a pH range of 6.5 to 7.5, while the PFP group is amine-reactive and is less prone to hydrolysis. The hydrophilic PEG linker enhances the water solubility of a compound in aqueous media, making it a versatile molecule for various applications.

Uses

Used in Bioconjugation:
Mal-PEG5-PFP is used as a bioconjugation agent for the selective and stable attachment of thiol-containing biomolecules, such as proteins or peptides, to other molecules or surfaces. The maleimide group reacts with thiols to form a stable bond, while the PFP group can be used for further amine-reactive modifications.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Mal-PEG5-PFP is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The hydrophilic PEG linker can enhance the water solubility of hydrophobic drugs, while the maleimide and PFP moieties can be used for conjugation to target molecules or for controlled release mechanisms.
Used in Diagnostics:
Mal-PEG5-PFP can be utilized as a component in diagnostic tools, such as imaging agents or sensors, due to its ability to form stable bonds with biomolecules and its hydrophilic nature. The maleimide and PFP groups can be used for the attachment of diagnostic labels or markers to biomolecules, while the PEG linker can improve the overall stability and solubility of the diagnostic system.
Used in Material Science:
In the field of material science, Mal-PEG5-PFP can be employed as a building block for the development of biocompatible and hydrophilic materials. The maleimide and PFP moieties can be used for the covalent attachment of biomolecules or other functional groups to the material, while the PEG linker can enhance the overall hydrophilicity and biocompatibility of the material.