Fluorescein-PEG4-Acid is a xanthene dye with excitation/emission maximum 494/517 nm and a free terminal carboxyl acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g., EDC or HATU) to form a stable amide bond. It can be used as a quantum yield standard. The hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding.
1807518-76-8
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Basic information
- Product Name: Fluorescein-PEG4-Acid
- Synonyms: Fluorescein-PEG4-Acid
- CAS NO:1807518-76-8
- Molecular Formula: C32H34N2O11S
- Molecular Weight: 654.68416
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1807518-76-8.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in Water, DMSO, DMF, DCM
- CAS DataBase Reference: Fluorescein-PEG4-Acid(CAS DataBase Reference)
- NIST Chemistry Reference: Fluorescein-PEG4-Acid(1807518-76-8)
- EPA Substance Registry System: Fluorescein-PEG4-Acid(1807518-76-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1807518-76-8(Hazardous Substances Data)
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1807518-76-8 Usage
Uses
Used in Bioconjugation:Fluorescein-PEG4-Acid is used as a bioconjugation agent for attaching biomolecules to other molecules or surfaces. The terminal carboxylic acid allows for stable amide bond formation with primary amine groups, enabling the attachment of proteins, peptides, or other amine-containing molecules.
Used in Fluorescence Imaging:
Fluorescein-PEG4-Acid is used as a fluorescent probe for imaging applications. Its excitation/emission maxima at 494/517 nm make it suitable for fluorescence microscopy, flow cytometry, and other imaging techniques. The hydrophilic PEG spacer enhances solubility in aqueous media, improving the dye's performance in biological samples.
Used in Drug Delivery Systems:
Fluorescein-PEG4-Acid can be used in drug delivery systems as a fluorescent marker to track the delivery and distribution of therapeutic agents. The PEG spacer can improve the solubility and biocompatibility of drug carriers, while the terminal carboxylic acid allows for the attachment of therapeutic agents or targeting moieties.
Used in Analytical Chemistry:
Fluorescein-PEG4-Acid can be used as a quantum yield standard in analytical chemistry. Its well-defined excitation/emission maxima and stable amide bond formation make it a reliable reference for fluorescence-based measurements and assays.
Used in Research and Development:
Fluorescein-PEG4-Acid can be used in research and development for the design and synthesis of new fluorescent probes, drug conjugates, and diagnostic tools. Its versatile chemistry and properties make it a valuable building block for the development of innovative applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 1807518-76-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,7,5,1 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.Calculate Digit Verification of CAS Registry Number 1807518-76:
(9*1)+(8*8)+(7*0)+(6*7)+(5*5)+(4*1)+(3*8)+(2*7)+(1*6)=188
188 % 10 = 8
So 1807518-76-8 is a valid CAS Registry Number.
1807518-76-8Upstream product
1807518-76-8Downstream Products
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Fluorescein-PEG4-Acid
