Azido-PEG1-NHS ester is a versatile click chemistry PEG reagent that enables the formation of stable triazole linkages through reactions with alkyne, BCN, and DBCO groups. Its NHS ester functionality allows for efficient labeling of primary amines, such as those found in proteins, amine-modified oligonucleotides, and other amine-containing molecules.
1807530-06-8
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Basic information
- Product Name: Azido-PEG1-NHS ester
- Synonyms: Azido-PEG1-NHS ester
- CAS NO:1807530-06-8
- Molecular Formula: C9H12N4O5
- Molecular Weight: 256.21538
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1807530-06-8.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in DMSO, DCM, DMF
- CAS DataBase Reference: Azido-PEG1-NHS ester(CAS DataBase Reference)
- NIST Chemistry Reference: Azido-PEG1-NHS ester(1807530-06-8)
- EPA Substance Registry System: Azido-PEG1-NHS ester(1807530-06-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1807530-06-8(Hazardous Substances Data)
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1807530-06-8 Usage
Uses
Used in Bioconjugation:Azido-PEG1-NHS ester is used as a bioconjugation agent for the covalent attachment of proteins, peptides, and other amine-containing molecules to various surfaces, nanoparticles, or other biomolecules. This enhances the stability, solubility, and bioactivity of the conjugated species.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Azido-PEG1-NHS ester is used as a drug delivery modifier to improve the pharmacokinetics, biodistribution, and therapeutic efficacy of drug molecules. The PEGylation of drugs using this reagent can reduce immunogenicity, increase solubility, and extend circulation time in the body.
Used in Diagnostic Imaging:
Azido-PEG1-NHS ester is employed as a contrast agent modifier in diagnostic imaging techniques such as magnetic resonance imaging (MRI), positron emission tomography (PET), and fluorescence imaging. The PEGylation of imaging agents using this reagent can enhance their stability, biocompatibility, and targeting capabilities.
Used in Tissue Engineering:
In the field of tissue engineering, Azido-PEG1-NHS ester is used as a component in the design of hydrogels and scaffolds for tissue regeneration. The incorporation of PEG-based structures can improve the biocompatibility, mechanical properties, and controlled release of bioactive factors from these engineered constructs.
Check Digit Verification of cas no
The CAS Registry Mumber 1807530-06-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,7,5,3 and 0 respectively; the second part has 2 digits, 0 and 6 respectively.Calculate Digit Verification of CAS Registry Number 1807530-06:
(9*1)+(8*8)+(7*0)+(6*7)+(5*5)+(4*3)+(3*0)+(2*0)+(1*6)=158
158 % 10 = 8
So 1807530-06-8 is a valid CAS Registry Number.
1807530-06-8Upstream product
1807530-06-8Downstream Products
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Azido-PEG1-NHS ester
