1807534-82-2

Basic information

• Product Name: Azido-PEG4-CH2CO2-NHS
• Synonyms: Azido-PEG4-CH2CO2-NHS;N3-PEG4-CH2CO2-NHS
• CAS NO: 1807534-82-2
• Molecular Formula: C14H22N4O8
• Molecular Weight: 374.34648
• Mol File: 1807534-82-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO, DCM, DMF
• CAS DataBase Reference: Azido-PEG4-CH2CO2-NHS(CAS DataBase Reference)
• NIST Chemistry Reference: Azido-PEG4-CH2CO2-NHS(1807534-82-2)
• EPA Substance Registry System: Azido-PEG4-CH2CO2-NHS(1807534-82-2)

Safety Data

• Hazardous Substances Data: 1807534-82-2(Hazardous Substances Data)

Usage

Description

Azido-PEG4-CH2CO2-NHS is a versatile click chemistry PEG reagent that features an azide group and an NHS ester. The hydrophilic PEG4 spacer enhances solubility in aqueous environments, while the azide group facilitates stable triazole linkage formation through click chemistry reactions with alkyne, BCN, and DBCO groups. The NHS ester enables efficient labeling of primary amines (-NH2) present in proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Uses

Used in Bioconjugation:
Azido-PEG4-CH2CO2-NHS is used as a bioconjugation agent for the covalent attachment of proteins, peptides, and other amine-containing molecules to various surfaces or other biomolecules. The NHS ester reacts with primary amines to form stable amide bonds, allowing for precise and specific modifications.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Azido-PEG4-CH2CO2-NHS is used as a component in drug delivery systems to improve the solubility, stability, and targeted delivery of therapeutic agents. The PEG spacer and azide group can be utilized to attach drugs or other functional groups via click chemistry, enhancing the overall performance of the drug delivery system.
Used in Diagnostics and Imaging:
Azido-PEG4-CH2CO2-NHS is employed as a labeling agent in diagnostic and imaging applications. The azide group can be used to attach imaging agents or other detectable moieties to biomolecules, enabling their tracking and visualization within biological systems.
Used in Materials Science:
In the field of materials science, Azido-PEG4-CH2CO2-NHS is used as a building block for the development of functional polymers and materials. The azide group allows for click chemistry-based crosslinking or modification of polymers, while the PEG spacer imparts beneficial properties such as increased solubility and reduced immunogenicity.