1807534-86-6

Basic information

• Product Name: 3,4-Dibromo-Mal-PEG2-Amine
• Synonyms: 3,4-Dibromo-Mal-PEG2-Amine;3,4-Dibromo-Mal-PEG2-Amine TFA salt
• CAS NO: 1807534-86-6
• Molecular Formula: C10H14Br2N2O4
• Molecular Weight: 386.03716
• Mol File: 1807534-86-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 425.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.831±0.06 g/cm3(Predicted)
• Solubility: Soluble in Water, DMSO, DCM, DMF
• PKA: 8.74±0.10(Predicted)
• CAS DataBase Reference: 3,4-Dibromo-Mal-PEG2-Amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dibromo-Mal-PEG2-Amine(1807534-86-6)
• EPA Substance Registry System: 3,4-Dibromo-Mal-PEG2-Amine(1807534-86-6)

Safety Data

• Hazardous Substances Data: 1807534-86-6(Hazardous Substances Data)

Usage

Description

3,4-Dibromo-Mal-PEG2-Amine is a versatile PEGylated compound featuring a dibromomaleimide group and a primary amine. The dibromomaleimide group provides two points of attachment through bromine substitution, while the primary amine enables reactions with carboxylic acids, activated NHS esters, and other carbonyl compounds. The hydrophilic nature of the PEG linker enhances the water solubility of the attached compound in aqueous media.

Uses

Used in Bioconjugation:
3,4-Dibromo-Mal-PEG2-Amine is used as a bioconjugation agent for the attachment of various biomolecules, such as proteins, peptides, and other functional groups. The reactive groups allow for stable covalent bonding, while the PEG linker improves solubility and reduces immunogenicity.
Used in Drug Delivery Systems:
In the pharmaceutical industry, 3,4-Dibromo-Mal-PEG2-Amine is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEGylation can also provide stealth properties, reducing clearance rates and extending the circulation time of the drug in the body.
Used in Material Science:
3,4-Dibromo-Mal-PEG2-Amine is used as a building block in the development of functional materials, such as hydrogels, micelles, and nanoparticles. The PEG linker and reactive groups facilitate the formation of well-defined structures with tailored properties for specific applications, including drug delivery, tissue engineering, and diagnostics.
Used in Chemical Synthesis:
In organic synthesis, 3,4-Dibromo-Mal-PEG2-Amine serves as an intermediate or a reagent for the preparation of various PEGylated compounds. The dibromomaleimide and primary amine functionalities enable the synthesis of complex molecules with desired properties, such as improved solubility, stability, or bioactivity.