1807537-42-3

Basic information

• Product Name: Mal-PEG5-NHS ester
• Synonyms: Mal-PEG5-NHS ester;Mal-PEG5-NHS
• CAS NO: 1807537-42-3
• Molecular Formula: C21H30N2O11
• Molecular Weight: 486.4697
• Mol File: 1807537-42-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO, DCM, DMF
• CAS DataBase Reference: Mal-PEG5-NHS ester(CAS DataBase Reference)
• NIST Chemistry Reference: Mal-PEG5-NHS ester(1807537-42-3)
• EPA Substance Registry System: Mal-PEG5-NHS ester(1807537-42-3)

Safety Data

• Hazardous Substances Data: 1807537-42-3(Hazardous Substances Data)

Usage

Description

Mal-PEG5-NHS ester is a PEG-based linker that features a maleimide group and an NHS ester group. The hydrophilic PEG chain enhances solubility in aqueous environments, while the NHS ester allows for the labeling of primary amines (-NH2) present in proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group is capable of reacting with thiol groups to form covalent bonds, facilitating the attachment of biomolecules with thiol groups.

Uses

Used in Bioconjugation:
Mal-PEG5-NHS ester is used as a bioconjugation agent for the attachment of thiol-containing biomolecules to amine-containing molecules. This is achieved through the reaction of the maleimide group with the thiol group and the NHS ester with the amine group, forming stable covalent bonds.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Mal-PEG5-NHS ester is used as a component in drug delivery systems to improve the solubility, stability, and targeting of therapeutic agents. The PEGylation of drugs can enhance their bioavailability and circulation time in the body, while the maleimide group allows for the attachment of drug molecules or targeting ligands with thiol groups.
Used in Diagnostics:
In diagnostic applications, Mal-PEG5-NHS ester is used for the development of imaging probes and biosensors. The PEG spacer improves the solubility and stability of the probes, while the maleimide and NHS ester groups enable the attachment of various diagnostic agents, such as fluorescent dyes or radioactive isotopes, to biomolecules of interest.
Used in Research and Development:
In research settings, Mal-PEG5-NHS ester is used as a tool for the creation of novel bioconjugates and the study of biomolecular interactions. The ability to attach a wide range of biomolecules through both thiol and amine groups makes it a versatile reagent for exploring new chemical and biological phenomena.