Mal-amido-PEG4-TFP ester is a PEGylated compound featuring a maleimide and TFP ester end group. The maleimide group is reactive with thiols within a pH range of 6.5 to 7.5, while the TFP ester can react with primary amine groups and is less prone to hydrolysis compared to NHS esters. The hydrophilic PEG chains enhance the water solubility of the compound in aqueous media, with longer PEG chains providing better water solubility than shorter ones.
1807540-84-6
Post Buying Request-
-
Basic information
- Product Name: Mal-amido-PEG4-TFP ester
- Synonyms: Mal-amido-PEG4-TFP ester;Mal-NH-PEG4-TFP
- CAS NO:1807540-84-6
- Molecular Formula: C24H28F4N2O9
- Molecular Weight: 564.4807328
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1807540-84-6.mol
-
Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in DMSO, DCM, DMF
- CAS DataBase Reference: Mal-amido-PEG4-TFP ester(CAS DataBase Reference)
- NIST Chemistry Reference: Mal-amido-PEG4-TFP ester(1807540-84-6)
- EPA Substance Registry System: Mal-amido-PEG4-TFP ester(1807540-84-6)
-
Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1807540-84-6(Hazardous Substances Data)
1807540-84-6 Suppliers
Recommended suppliers
1807540-84-6 Usage
Uses
Used in Bioconjugation:Mal-amido-PEG4-TFP ester is used as a bioconjugation agent for the selective attachment of thiol-containing biomolecules, such as proteins or peptides, due to its reactive maleimide group. This allows for the formation of stable thioether linkages under mild conditions.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Mal-amido-PEG4-TFP ester is used as a drug delivery agent to improve the solubility and stability of therapeutic agents. The PEGylation enhances the water solubility and bioavailability of drugs, while the TFP ester allows for the conjugation of primary amine-containing drugs, creating a stable amide bond.
Used in Diagnostic Imaging:
Mal-amido-PEG4-TFP ester is utilized as a contrast agent in diagnostic imaging applications. The PEGylation improves the solubility and circulation time of imaging agents, while the maleimide and TFP ester groups enable the conjugation of imaging probes, such as fluorescent dyes or radionuclides, to biomolecules for targeted imaging.
Used in Cosmetics:
In the cosmetics industry, Mal-amido-PEG4-TFP ester is used as a solubility enhancer for hydrophobic active ingredients. The PEGylation increases the water solubility of these ingredients, allowing for their incorporation into aqueous cosmetic formulations and improving their overall performance.
Check Digit Verification of cas no
The CAS Registry Mumber 1807540-84-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,7,5,4 and 0 respectively; the second part has 2 digits, 8 and 4 respectively.Calculate Digit Verification of CAS Registry Number 1807540-84:
(9*1)+(8*8)+(7*0)+(6*7)+(5*5)+(4*4)+(3*0)+(2*8)+(1*4)=176
176 % 10 = 6
So 1807540-84-6 is a valid CAS Registry Number.
1807540-84-6Upstream product
1807540-84-6Downstream Products
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 1807540-84-6
Mal-amido-PEG4-TFP ester
