180776-29-8

Upstream product

• 180776-28-7 (S)-2-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-pent-4-enoic acid 
• 100-51-6 benzyl alcohol 
• 180776-27-6 (3aS,8aR)-3-[(S)-2-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-pent-4-enoyl]-3,3a,8,8a-tetrahydro-indeno[1,2-d]oxazol-2-one 
• 180776-26-5 (3aS,8aR)-3-[3-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-propionyl]-3,3a,8,8a-tetrahydro-indeno[1,2-d]oxazol-2-one 
• 180776-47-0 3-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-propionic acid ethyl ester 
• 180776-25-4 3-((3aR,4R,6R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-propionic acid 
• 131121-18-1 (E)-ethyl 3-((3aR,4R,6R,6aR)-tetrahydro-4-methoxy-2,2-dimethylfuro[3,4-d][1,3]dioxol-6-yl)acrylate 
• 4099-85-8 ((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 
• 532-20-7 D-Ribose 
• 33985-40-9 (3aR,4S,6R,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro-[3,4-d][1,3]dioxole-4-carbaldehyde 

Downstream Products

• 1431134-96-1 C₃₉H₄₆N₂O₁₀ 
• 1403482-48-3 C₂₇H₃₄INO₆ 
• 1403482-46-1 C₂₂H₃₂INO₆ 
• 1403482-45-0 C₂₁H₃₀INO₆ 
• 1403482-38-1 C₂₂H₃₃NO₈ 
• 1403482-40-5 C₂₂H₃₁NO₆ 
• 1403482-39-2 C₂₅H₃₇NO₈ 
• 1431134-81-4 C₃₀H₄₀N₂O₈ 
• 1431134-85-8 C₂₅H₃₈N₂O₈ 
• 1431134-87-0 C₂₃H₃₁NO₇ 
• 1431135-34-0 C₂₂H₃₁NO₇ 
• 1431134-84-7 C₂₁H₂₉NO₇ 
• 1403482-56-3 C₃₈H₄₆N₂O₁₀ 
• 1403482-54-1 C₃₃H₄₄N₂O₁₀ 

Relevant academic research and scientific papers

COFACTOR ANALOGS AS METHYLTRANSFERASE INHIBITORS FOR TREATING CANCER

Compounds having methyltransferase inhibitory activity are disclosed. The compounds have the structure (I) They are useful in the treatment of cancer and similar diseases associated with inappropriate methyltransferase activity.

Total synthesis of (+)-sinefungin

Sinefungin (1) a nucleoside antibiotic isolated from Streptomyces has been synthesized from D-ribose. Both the C-6 and C-9 stereogenic centers were constructed by efficient asymmetric syntheses. The C-6 amine stereochemistry was set by a highly diastereoselective allylation (> 99% de) of a (1S,2R)-1-amino-2-indanol-derived oxazolidinone 9 followed by a Curtius rearrangement of 11 to 12. The C-9 amino acid stereochemistry of sinefungin (1) was established by a rhodium chiral bisphosphine-catalyzed asymmetric hydrogenation of an α-(acylamino)acrylate derivative. The anomeric adenosylation of the mixture of anomeric acetates 20 in the presence of C-6 urethane NH was found to be extremely difficult. Conversion of the C-6 urethane NH as its N-benzyl derivative 21 was necessary prior to the adenosylation reaction. Successful adenosylation was effectively carried out by Vorbruggen's protocol utilizing persilylated N6-benzoyladenine and trimethylsilyl triflate.