180841-67-2

Upstream product

• 753-73-1 dimethyltin dichloride 
• 54-21-7 sodium salicylate 
• 69-72-7 salicylic acid 

Relevant academic research and scientific papers

Bis(2-hydroxybenzoato-O,O')dimethyltin

The Sn atom in [Sn(C7H5O3)2(CH3) 2] is in a skew trapezoidal bipyramidal geometry with two types of Sn-O bond distances of approximately 2.1 and 2.5 A. The methyl substituents lie over the weaker Sn...O interactions. The weakly bonded O atoms are involved in intramolecular hydrogen-bonding contacts with the hydroxyl groups. In addition, there is a close intermolecular contact between one of the weakly associated O atoms and a symmetry-related hydroxyl group.

Cytotoxic effect, antitumour activity and toxicity of organotin derivatives with ortho- or para-hydroxy-benzoic acids

The cytotoxic and antitumour activities of five organotin complexes (1–5) with o-hydroxy-benzoic or p-hydroxy-benzoic acids were evaluated in a series of in vitro and in vivo experiments. All complexes exhibited strong cytotoxic activity against all cancer cells lines, whereas complexes 1, 2 and 4 induced apoptosis at significantly lower doses than complexes 3 and 5. Human cancer cells treated with increasing concentrations of complexes 1, 2 and 4 gradually lost their ability to form colonies. Only complexes 1 and 2 inhibited colony formation efficiency in rat leiomyosarcoma cells. Histopathology of liver and kidney showed mild damage and lung oedema after a single injection of 10 mg/kg body wt of complex 1 to Wistar rats. At higher doses (100 mg/kg body wt) brain stem oedema was observed. Daily administration of tumour-bearing Wistar rats (leiomyosarcoma) with 1 mg/kg body wt of complex 1 until death reduced the mean tumour growth rate by more than 3× fold and prolonged mean survival time by 120%. These findings indicate that the organotin complexes with ortho- or para-hydroxy-benzoic acids possess potent cytotoxic and antitumour activity and they could be used as potential chemotherapeutic agents.