180859-46-5

Upstream product

• 180859-27-2 2-[3'-(4''-chlorophenyl)-4',6'-dimethoxyindol-2'-yl]glyoxyloyl chloride 
• 151290-21-0 3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole 
• 180859-33-0 2-[3-(4-Chloro-phenyl)-4,6-dimethoxy-1H-indol-2-yl]-N,N-dimethyl-2-oxo-acetamide 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Formation of C-amido-calix[3]indoles from 2'- and 7'-indolylglyoxylamides

A range of 2'- and 7'-indolylglyoxylic amides 1 and 2, derived from 3-(4'-chlorophenyl)-4,6-dimethoxyindole, have been reduced to the corresponding alcohols 3 and 4 respectively. On treatment with acid, these alcohols underwent trimerisation to give the calix[3]indoles 8. The major conformer was generally the flattened partial cone, but in certain cases the cone conformers could be detected and even isolated. The related 2'-indolylglyoxylic amides 13, derived from 4,6-dimethoxy-3-methylindole, were also converted into calix[3]indoles 15. (C) 2000 Elsevier Science Ltd.

Reaction of some 4,6-dimethoxyindoles with oxalyl chloride

3-(4'-Chlorophenyl)-4,6-dimethoxyindole 1 undergoes reaction with oxalyl chloride to give the corresponding 2- and 7-glyoxyloyl chloride derivatives in differing proportions depending on the solvent and reaction temperature. The glyoxyloyl chlorides 2 and 3 were converted into the related glyoxylic acids, and also a wide range of glyoxylic esters and amides 4 and 5 respectively.