180863-48-3

Upstream product

• 180863-47-2 N-(1(S)-carbomethoxy-3-methylthiopropyl)3-azidomethylbenzamide 
• 180863-46-1 N-(1(S)-carbomethoxy-3-methylthiopropyl)3-chloromethylbenzamide 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 160813-66-1 N-(1(S)-carbomethoxy-3-methylthiopropyl)3-aminomethylbenzamide 

Downstream Products

• 180863-59-6 4-methylsulfanyl-2-(3-{[methyl-(1-trityl-1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-butyric acid methyl ester 
• 180863-37-0 2-(3-{[(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester 
• 245126-55-0 2-[3-({(4-cyano-benzyl)-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid methyl ester 
• 245126-51-6 2-[3-({(4-cyano-benzyl)-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid 
• 245126-54-9 2-[3-({butyl-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid methyl ester 
• 245126-53-8 2-[3-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid methyl ester 
• 180863-43-8 2-(3-{[(1H-imidazol-4-ylmethyl)-(4-nitro-benzyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester 
• 245126-52-7 2-(3-{[(4-cyano-benzyl)-(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester 

Relevant academic research and scientific papers

Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase

The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Substitutions on an imidazolylmethyl-AMBA- methionine template gave a highly potent and cell-active inhibitor.