18090-77-2

Upstream product

• 727985-40-2 (5R)-5-methyl-7-methyleneindolizidin-one 
• 727985-43-5 (5R,9R)-5-methyl-7-methyleneindolizidine 
• 910106-40-0 (2R,4S,6R)-(-)-N-benzoxycalboyl-4,6-dimethyl-3-methylesterpropylpiperidine 
• 910106-43-3 (2R,4S,6R)-(-)-N-benzoxycalboyl-4,6-dimethyl-2-hydroxypropylpiperidine 
• 461641-14-5 4-[3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-5-isopropyl-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid ethyl ester 
• 727985-47-9 (5R,7S,8aR)-(-)-5,7-dimethylindolizidine-3-one 
• 910106-37-5 (1S,2R)-(-)-cis-1-[(2R,4S,6R)-2-(3-tert-butyldimethylsiloxypropyl)-4-hydroxymethyl-6-methylpiperidin-1-yl]-7-isopropylindan-2-ol 
• 910106-34-2 4-[3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-5-isopropyl-1,3,4,9,9a,10a-hexahydro-2H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid ethyl ester 
• 910106-36-4 {4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-5-isopropyl-1,3,4,9,9a,10a-hexahydro-2H,4bH-10-oxa-4a-aza-indeno[1,2-a]inden-2-yl}-methanol 
• 910106-41-1 {4-[3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-5-isopropyl-1,3,4,9,9a,10a-hexahydro-2H,4bH-10-oxa-4a-aza-indeno[1,2-a]inden-2-yl}-methanol 
• 910106-42-2 (2R,4S,6R)-(-)-N-benzoxycalboyl-2-(3-tert-butyldimethylsilyloxypropyl)-4-bromomethyl-6-methylpiperidine 
• 910106-38-6 (2R,4S,6R)-(-)-N-benzyzoxycalboyl-2-(3-tert-butyldimethylsilyloxypropyl)-4-hydroxymethyl-6-methylpiperidine 
• 910106-39-7 (2R,4S,6R)-(-)-N-benzoxycalboyl-2-(3-tert-butyldimethylsilyloxypropyl)-4,6-dimethylpiperidine 

Relevant academic research and scientific papers

Synthesis of 2,4,6-trisubstituted chiral piperidines and (-)-dendroprimine by one-pot asymmetric azaelectrocyclization protocol

Stereocontrolled synthesis of 2,4,6-trisubstituted piperidine diastereomers has been realized from common intermediates, obtained by a one-pot azaelectrocyclization protocol. Based on the method, the asymmetric synthesis of an indolizidine alkaloid, (-)-d

Stereocontrolled synthesis of substituted chiral piperidines viaone-pot asymmetric 6π-azaelectrocyclization: Asymmetric syntheses of(-)-dendroprimine, (+)-7-epidendroprimine, (+)-5-epidendroprimine, and (+)-5,7-epidendroprimine

The asymmetric one-pot 6π-azaelectrocyclization of alkenyl vinyl stannane, ethyl (Z)-2-iodo-4-oxobutenoate, and (-)-7-isopropyl-cis-aminoindanol in the presence of a Pd(0) catalyst stereoselectively produced the tetracyclic aminoacetal compounds, resultin

Enantioselective synthesis of (-)-dendroprimine and isomers

An enantioselective and diastereoselective synthesis of six 5,7-dimethylindolizidine isomers is described via an intramolecular cyclization that involves an allylsilyl nucleophilic group and an acyliminium ion. The first total synthesis of naturally occurring (-)-dendroprimine has been achieved in five steps.