180906-56-3Relevant academic research and scientific papers
A facile synthesis of optically active β-amino-β- arylethylphosphonates by mitsunobu reaction
Xu, Chengfu,Yuan, Chengye
, p. 4410 - 4415 (2004)
We describe a convenient and simple synthesis of optically active β-amino-β-arylethylphosphonates based on Mitsunobu reactions of chiral β-aryl-β-hydroxyethylphosphonates, prepared in turn by Candida rugosa lipase catalyzed kinetic resolution of the corresponding racemates. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
Rhodium-catalyzed asymmetric hydrogenation of unprotected β-enamine phosphonates
Zhou, Ming,Xue, Zejian,Cao, Min,Dong, Xiu-Qin,Zhang, Xumu
, p. 4582 - 4584 (2016)
We have successfully developed a strategy for the first time for the enantioselective Rh-TaniaPhos catalyzed asymmetric hydrogenation of unprotected β-enamine phosphonates to free β-amino phosphonates directly with good enantioselectivities (80%-86% ee) a
Sulfonyl as a Traceless Activation Group for Enantioselective Mannich Reaction Catalyzed by Thiourea to Access Chiral β-Aminophosphonates
Peng, Yungui,Ning, Yanqiang,Tan, Songlin,Li, Dezhong,Liao, Na
, p. 678 - 682 (2018/01/27)
An efficient enantioselective Mannich reaction of N -protected α-sulfones with β-benzenesulfonyl phosphonates was developed by using a chiral cinchona alkaloid-derived thiourea as a catalyst. This method was used to obtain a series of chiral α-sulfonyl-β-aminophosphonates in yields of up to 96% with 89:11 dr and 88% ee. These compounds were further transformed into β-aminophosphonates or chiral azetidines with various functional groups by a Horner-Wadsworth-Emmons/aza-Michael addition reaction sequence.
