180911-97-1Relevant academic research and scientific papers
A process for preparing 1, 2 - dihydro - (4 H) - 3, 1 - benzoxazin -4 - ketone compound method
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Paragraph 0091-0094, (2019/04/14)
The invention discloses a method for utilizing N - methyl - N - aryl anthranilic acid compound synthesis of 1, 2 - dihydro - (4 H) - 3, 1 - benzoxazin - 4 - ketone compounds, the synthetic method is: the palladium salt as a catalyst, the N - methyl - N -
Pd-Catalyzed Intramolecular Chemoselective C(sp2)-H and C(sp3)-H Activation of N-Alkyl- N-arylanthranilic Acids
Hu, Zhe-Yao,Zhang, Yan,Li, Xin-Chang,Zi, Jing,Guo, Xun-Xiang
supporting information, p. 989 - 992 (2019/05/16)
A controllable palladium-catalyzed intramolecular C-H activation of N-alkyl-N-arylanthranilic acids has been developed. The methodology allows selective synthesis of 1,2-dihydro-(4H)-3,1-benzoxazin-4-ones and carbazoles from the same starting materials and palladium catalyst. The selectivity is controlled by the oxidant. Silver oxide promotes C(sp3)-H activation/C-O cyclization to provide 1,2-dihydro-(4H)-3,1-benzoxazin-4-ones, while copper acetate contributes to C(sp2)-H activation/decarboxylative arylation to afford carbazoles. This protocol is demonstrated by its wide substrate scope and good functional group tolerance.
NIS-mediated intramolecular oxidative α-functionalization of tertiary amines: Transition metal-free synthesis of 1,2-dihydro-(4H)-3,1-benzoxazin-4-one derivatives
Liu, Le,Du, Liang,Zhang-Negrerie,Du, Yunfei
, p. 29774 - 29781 (2015/05/20)
A novel method for direct α-functionalization of tertiary amines via NIS-mediated oxidative C-O bond formation, where NIS serves as both an oxidant and an iodination reagent, has been developed. The method provides easy access to either iodinated or non-iodinated 1,2-dihydro-(4H)-3,1-benzoxazin-4-ones, depending on the nature of the reactant, via a regioselective transition metal-free approach. This journal is
