180915-78-0Relevant articles and documents
Enzyme-catalyzed asymmetric deacylation for the preparation of Lasofoxifene (CP-336156), a selective estrogen receptor modulator
Yang, Xiaojing,Reinhold, Anthony R.,Rosati, Robert L.,Liu, Kevin K.-C
, p. 4025 - 4027 (2000)
(Matrix presented) A potent and selective estrogen receptor modulator (SERM), Lasofoxifene (CP-336156), was prepared by an enzyme-catalyzed asymmetric deacylation with high optical purity and excellent yield even though the hydrolytic site is remote from
LASOFOXIFENE MODULATION OF MEMBRANE-INITIATED ESTROGEN SIGNALS AND METHODS FOR TUMOR TREATMENT
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, (2018/08/03)
The present invention found that lasofoxifene is an antagonist of ER-α36. It not only inhibits the growth of ER-α36 positive lung, colon and gastric cancers, and also it can inhibit the growth of acquired or de novo tamoxifen-resistant MCF-7 cells. Our finding also provides methods and compositions for treating cancer comprising lasofoxifene alone or in combination with at least one other agent selected from the group consisting of gefitinib and/or trastuzumab or functional equivalent thereof, and an inhibitor in hormonal or epidermal growth factor signal transduction pathways.
An ortho-quinodimethane route to Lasofoxifene and U23469
Yoshida, Hiroto,Yoshida, Ryuma,Mukae, Masashi,Ohshita, Joji,Takaki, Ken
supporting information, p. 1272 - 1274 (2015/09/22)
Lasofoxifene, a third-generation selective estrogen receptor modulator, could be synthesized via regio-and stereoselective [4 + 2] cycloaddition between an ortho-quinodimethane and a borylalkene. This protocol was also applicable to the synthesis of antie
A PROCESS FOR THE PREPARATION OF LASOFOXIFENE TARTRATE
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Page/Page column 21, (2010/11/17)
The present invention relates to solid state chemistry of 1-(2-[4-(6-methoxy-3,4-dihydronaphthalene-1-yl) phenoxy]ethyl)pyrrolidine, a process for its preparation and its use as an intermediate in the synthesis of lasofoxifene.