18092-17-6

Basic information

• Product Name: (2-hydroxy-5-oxo-1-phenyl-4,5-dihydro-1H-pyrrol-3-yl)(triphenyl)phosphonium
• CAS NO: 18092-17-6
• Molecular Formula: C₂₈H₂₂NO₂P
• Molecular Weight: 436.4609
• Mol File: 18092-17-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2-hydroxy-5-oxo-1-phenyl-4,5-dihydro-1H-pyrrol-3-yl)(triphenyl)phosphonium(CAS DataBase Reference)
• NIST Chemistry Reference: (2-hydroxy-5-oxo-1-phenyl-4,5-dihydro-1H-pyrrol-3-yl)(triphenyl)phosphonium(18092-17-6)
• EPA Substance Registry System: (2-hydroxy-5-oxo-1-phenyl-4,5-dihydro-1H-pyrrol-3-yl)(triphenyl)phosphonium(18092-17-6)

Safety Data

• Hazardous Substances Data: 18092-17-6(Hazardous Substances Data)

Usage

General Description

This chemical, also known as Cyclic triphosphonium salt, is an organic compound that consists of a phosphonium cation attached to a pyrrole moiety. It is a member of the phosphonium compound family and is commonly used in organic synthesis and as a catalyst in various chemical reactions. The compound is characterized by its aromatic phenyl and triphenylphosphine groups, as well as its 2-hydroxy-5-oxo-1-phenyl-4,5-dihydro-1H-pyrrol-3-yl functional group. It has been studied for its potential applications in medicinal chemistry, particularly in the development of novel drugs and pharmaceuticals. Additionally, it exhibits interesting properties that make it a valuable tool in organometallic chemistry and materials science.

Upstream product

• 941-69-5 N-phenyl-maleimide 
• 603-35-0 triphenylphosphine 
• 62-53-3 aniline 

Downstream Products

• 1233975-63-7 N-phenyl-1,6-methano[10]annulene-3,4-dicarboximide 

Relevant articles and documents

Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists

A series of 4-(phenoxymethyl)thiazole derivatives was synthesized and evaluated for their GPR119 agonistic effect. Several 4-(phenoxymethyl)thiazoles with pyrrolidine-2,5-dione moieties showed potent GPR119 agonistic activities. Among them, compound 27 and 32d showed good in vitro activity with an EC50 value of 49 nM and 18 nM, respectively with improved human and rat liver microsomal stability compare with MBX-2982. Compound 27 & 32d did not exhibit significant CYP inhibition, hERG binding, and cytotoxicity. Moreover, these compounds lowered the glucose excursion in mice in an oral glucose-tolerance test.

Iridium-catalyzed asymmetric hydrogenation of α-alkylidene succinimides

Not to be out PhOXed! The title reaction provides a new approach to chiral succinimide derivatives with excellent yields and ee values by using a low catalyst loading (0.05 mol %) and mild reaction conditions. Chiral 3-benzyl pyrrolidines and 1-hydroxypyrrolidine-2,5-diones, important structural motifs in natural products and pharmaceuticals, could be readily prepared. BARF -=tetrakis[3,5-bis(trifluoromethyl)phenyl]borate. Copyright