18093-92-0

Usage

General Description

1H-Pyrazole-4-carbonitrile, 3-methyl-1-phenyl- is a chemical compound with the molecular formula C10H8N4. It is a derivative of pyrazole and contains a carbonitrile group, as well as a methyl and phenyl substituent. 1H-Pyrazole-4-carbonitrile, 3-methyl-1-phenyl- is commonly used in organic synthesis and pharmaceutical research due to its potential pharmacological applications. It may also have uses in the development of agrochemicals and other specialty chemicals. Its precise properties, uses, and potential hazards are subject to ongoing research and evaluation.

Upstream product

• 96286-04-3 3-Methyl-1-phenyl-1H-pyrazole-4-carbaldehyde oxime 
• 50877-45-7 4-bromo-3-methyl-1-phenyl-1H-pyrazole 
• 21487-48-9 3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 5346-56-5 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile 

Downstream Products

• 1128-54-7 3-methyl-1-phenyl-1H-pyrazole 
• 137813-13-9 Ethyl 2-<4-(1-phenyl-3-methylpyrazolyl)>-4-thiazolylacetate hydrochloride 
• 137576-97-7 2-<4-(1-Phenyl-3-methylpyrazolyl)>-4-thiazolylacetic acid 
• 137576-92-2 2-<4-(1-Phenyl-3-methylpyrazolyl)>-4-thiazolylcarboxylic acid 
• 137576-87-5 1-Phenyl-3-methyl-4-pyrazolethiocarboxamide 

Relevant academic research and scientific papers

Aryl Nitriles from Alkynes Using tert -Butyl Nitrite: Metal-Free Approach to C≡C Bond Cleavage

Alkyne C≡C bond breaking, outside of alkyne metathesis, remains an underdeveloped area in reaction discovery. Recently, nitrogenation has been reported to allow nitrile formation from alkynes. A new protocol for the metal-free C≡C bond cleavage of terminal alkynes to produce nitriles is reported. This method provides an opportunity to synthesize a vast range of nitriles containing aryl, heteroaryl, and natural product derivatives (38 examples). In addition, the potential of tBuONO to act as a powerful nitrogenating agent for terminal aryl alkynes is demonstrated. (Figure Presented).

Transformations of phenylhydrazones of 5-acyl-1,2,4-triazines to pyrazolo[4,3-e][1,2,4]triazines or 4-cyanopyrazole

(Chemical Equation Presented) A simple and high yielding preparation of pyrazolo[4,3-e][1,2,4]triazines and 4-cyano-3-methyl-1-phenylpyrazole derivatives from corresponding phenylhydrazones of 5-acyl-1,2,4-triazines by melt under acidic medium and by ther

GROUP DIPOLE MOMENTS OF SUBSTITUENTS AT POSITIONS 4 AND 5 OF NITROGEN-CONTAINING FIVE-MEMBERED HETEROCYCLES

The dipole moments of the 5-chloro-4-cyano derivatives of oxazole, thiazole, imidazole, and pyrazole were determined.The group dipole moments of substituents at positions 2 and 3 of furan, thiophene, and pyrrole can be used for vector calculation of the dipole moments of various 4- and 5-substituted azoles.