180967-70-8

Upstream product

• 6142-95-6 phenylpropargyl aldehyde diethyl acetal 
• 163271-80-5 3-triisopropylsilyl-2-propynal 
• 180967-62-8 4-(benzotriazol-1-yl)-4-ethoxy-6-phenyl-1-triisopropylsilyl-hexa-1,5-diyn-3-ol 
• 171815-69-3 1-(benzotriazol-1-yl)propargyl ethyl ether 
• 180967-66-2 4-Benzotriazol-1-yl-4-ethoxy-6-phenyl-1-triisopropylsilanyl-hexa-1,5-diyn-3-one 

Relevant academic research and scientific papers

1,2-dialkinylated compounds

PCT No. PCT/EP97/03340 Sec. 371 Date May 20, 1998 Sec. 102(e) Date May 20, 1998 PCT Filed Jun. 25, 1997 PCT Pub. No. WO98/00386 PCT Pub. Date Jan. 8, 1998The present invention is relative to 1,2-dialkynylated compounds, especially dialkynyl-1,2-diones, a

One-step synthesis of dialkynyl-1,2-diones and their conversion to fused pyrazines bearing enediyne units

A convenient procedure for the preparation of symmetrically end-protected dialkynyl-1,2-diones 3 from lithium acetylides and oxalyl chloride in the presence of CuBr and LiBr is described. The condensation of 3 with various aromatic and heteroaromatic 1,2-diamines leads to pyrazine-based α-dialkynylated heterocycles. The enediyne substructure of diethynylquinoxaline can be thermally rearranged in a Bergman cyclization reaction.

Terminally protected 1-phenyl-1,5-hexadiyne-3,4-diones as first members of the class of dialkynyl-1,2-diones

Reaction of lithiated 1-(1-ethoxy-3-phenyl-prop-2-ynyl)-1H-benzotriazole (3) with various acetylenic aldehydes followed by periodinane oxidation and hydrolysis yields terminally protected 1-phenyl-1,5-hexadiyne-3,4-diones 7a-d as the first examples of dialkynyl-1,2-diones. VCH Verlagsgesellschaft mbH, 1996.