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Upstream product

• 150-13-0 4-amino-benzoic acid 
• 22278-81-5 4-amino-6-methyl-3-thio-1,2,4-triazin-5-one 
• 22278-81-5 4-amino-5-oxo-3-thioxo-6-methyl-2,3,4,5-tetrahydro<1,2,4>triazine 

Relevant academic research and scientific papers

Synthesis and biological studies of some new thiadiazolo [2,3-a] 1,2,4-triazin-5-ones

Treatment of thiocarbohydrazide 2 with pyruvic acid 1 in ethanol affords 4-amino-3-mercapto-6-methyl-1,2,4-triazin-5(4H)-one 3. Cyclization of 3 with various aromatic acids in presence of phosphorus oxychloride yields 2-substituted -6-methyI-4H-1,3,4-thiadiazolo [2,3-c], 1,2,4-triazin-5-ones (4a-j). The structures of the newly synthesized compounds have been established by means of IR, Mass, 1H NMR spectral data. All the new compounds (4a-j) were evaluated for their antibacterial and antifungal activities.

Heterocyclic monoazo dyes derived from 2-(p-aminophenyl)oxazolo[4,5-b]pyridine and 7-(p-aminophenyl)- 4H-[1,3,4]thiadiazolo[2,3-c] [1,2,4]triazin-4-one

2-(p-Aminophenyl)oxazolo [4,5-b]pyridine (1; y = O) has been diazotized and coupled with aniline, N,N-diethylaniline and phenol giving the monoazo dyes 2. These compounds are quaternized to give the cationic dyes 9 and 10, 4-Amino-6- methyl-1,2,4-triazine-3(2H)-thion-5-one 4 is reacted with p-aminobenzoic acid in polyphosphoric acid to afford 7-(p-aminophenyl)-3-methyl-4H[1,3,4]thiadiazolo[2,3-c][1,2,4] triazin-4-one 3, A series of monoazo dyes has been obtained using aniline, N,N-diethylaniline and phenol as coupling components and diazotized 3 as diazo compound.

Synthesis and biological activity studies of 1,3,4-thiadiazolo[2,3-c]-as-triazines

Several new 1,3,4-thiadiazolo[2,3-c]-as-triazines were synthesized by the reaction of 6-substituted-4-amino-3-mercapto-1,3,4-triazon-5(4H)-ones with appropriate aromatic and heterocyclic carboxylic acids in the presence of phosphorus oxichloride. The structures of the newly synthesized compounds were established on the basis of analytical, IR, NMR and mass spectral data. Some selected compounds from this series were subjected to both antimicrobial and pharmacological studies.