180981-83-3Relevant academic research and scientific papers
Scavenger assisted combinatorial process for preparing libraries of tertiary amine compounds
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, (2008/06/13)
This invention relates to a novel solution phase process for the preparation of tertiary amine combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.
Synthesis of an enantiomerically pure aminoisoquinocarbazole with antiarrhythmic activity via lipase-catalyzed enantioselective transesterification
Fukazawa, Tetuya,Shimoji, Yasuo,Hashimoto, Toshihiko
, p. 1649 - 1658 (2007/10/03)
Enantiomerically pure (R)-2-cyclohexen-1-ol 5 was prepared via lipase- catalyzed enantioselective transesterification of 2-substituted cyclohexanol, and stereospecifically converted to (-)-(2-cyclohexenyl)acetic acid 4. Enantiomerically pure aminoisoquinocarbazole 1 (RS-2135) was synthesized stereoselectively from 4, using an intramolecular Diels-Alder reaction and Curtius rearrangement.
