181045-86-3

Upstream product

• 91604-41-0 (R,R)-1,4-dibenzylthreitol 
• 107802-80-2 (2S,3R,4R,5S,6R)-3,4,5-Tris-benzyloxy-2-methyl-6-methylsulfanyl-tetrahydro-pyran 

Downstream Products

• 181045-88-5 {(2R,3R,4S,5S,6R)-3,5-Bis-benzyloxy-2-[(1R,2R)-3-benzyloxy-1-benzyloxymethyl-2-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-propoxy]-6-benzyloxymethyl-tetrahydro-pyran-4-yloxy}-acetic acid benzyl ester 

Relevant academic research and scientific papers

Mimics of the sialyl Lewis X tetrasaccharide. Replacement of the N- acetylglucosamine sugar with simple C2-symmetric 1,2-diols

Analogues of sialyl Lewis X have been synthesized that feature replacement of the N-acetylglucosamine residue with C2-symmetric diols. The diols used contain different levels of torsional constraint and various functional groups. The cyclohexyl derived compound 27 was equipotent to sLex in vitro (IC50 0.5 mM).