181048-48-6

Basic information

• Product Name: 2-(4-TERT-BUTYL-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID
• Synonyms: 2-(4-TERT-BUTYL-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID
• CAS NO: 181048-48-6
• Molecular Formula: C₂₀H₁₉NO₂
• Molecular Weight: 305.37
• Mol File: 181048-48-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-TERT-BUTYL-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-TERT-BUTYL-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID(181048-48-6)
• EPA Substance Registry System: 2-(4-TERT-BUTYL-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID(181048-48-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 181048-48-6(Hazardous Substances Data)

Usage

General Description

2-(4-tert-butyl-phenyl)-quinoline-4-carboxylic acid is a chemical compound with the molecular formula C24H21NO2. It is a quinoline derivative that contains a carboxylic acid group and a tert-butyl-phenyl group. 2-(4-TERT-BUTYL-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID has potential applications in pharmaceuticals and materials science due to its unique structure and properties. It may be used as a starting material for the synthesis of other organic compounds or as a building block in the development of new drugs or materials. Its precise uses and functions will depend on further research and development in the field of chemistry and pharmacology.

Upstream product

• 943-27-1 4'-t-butylacetophenone 
• 91-56-5 indole-2,3-dione 

Relevant articles and documents

Phenylquinoline transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of 1-(2-phenylquinoline-4-carbonyl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide

Reported herein is the design, synthesis, and pharmacologic characterization of a class of TRPV1 antagonists constructed on a phenylquinoline platform that evolved from Cinchophen lead. This design composes three sections: a phenylquinoline headgroup attached to an aliphatic carboxamides, which is tethered at a phenyl tail group. Optimization of this design led to the identification of 37, comprising a pyrrolidine linker and a trifluoromethyl–phenyl tail. In the TRPV1 functional assay, using cells expressed hTRPV1, 37 antagonized capsaicin-induced Ca2+ influx, with an IC50 value of 10.2 nM. In the complete mice analgesic model, 37 exhibited better antinociceptive activity than the positive control BCTC in diverse pain models. All of these results suggested that 37 could be considered as a lead candidate for the further development of antinociceptive drugs.