181048-72-6

Basic information

• Product Name: (Rp)-5'-dimethoxytritylthymidine-3'-methylphosphonic-di-n-butylphosphiothioic anhydride
• CAS NO: 181048-72-6
• Molecular Weight: 798.874
• Mol File: 181048-72-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Rp)-5'-dimethoxytritylthymidine-3'-methylphosphonic-di-n-butylphosphiothioic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: (Rp)-5'-dimethoxytritylthymidine-3'-methylphosphonic-di-n-butylphosphiothioic anhydride(181048-72-6)
• EPA Substance Registry System: (Rp)-5'-dimethoxytritylthymidine-3'-methylphosphonic-di-n-butylphosphiothioic anhydride(181048-72-6)

Safety Data

• Hazardous Substances Data: 181048-72-6(Hazardous Substances Data)

Upstream product

• 108203-06-1 5'-dimethoxytritylthymidine-3'-methylphosphonate 
• 55656-88-7 di-n-butylthioxophosphoranyl bromide 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 

Relevant articles and documents

Stereocontrolled synthesis of nucleoside-methylphosphonate-methyl ester diastereomers from mixed anhydride

Nucleoside-3'-methylphosphonate was converted to a diastereomeic mixture of di-n-butylphosphiothioic anhydride and the stereoisomers were separated. Activation of each isomer with silver nitrate and coupling with methanol resulted in the formation of a methyl ester with inversion of configuration.