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181053-90-7

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181053-90-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 181053-90-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,0,5 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 181053-90:
(8*1)+(7*8)+(6*1)+(5*0)+(4*5)+(3*3)+(2*9)+(1*0)=117
117 % 10 = 7
So 181053-90-7 is a valid CAS Registry Number.

181053-90-7Downstream Products

181053-90-7Relevant articles and documents

Discovery of an MLLT1/3 YEATS Domain Chemical Probe

Moustakim, Moses,Christott, Thomas,Monteiro, Octovia P.,Bennett, James,Giroud, Charline,Ward, Jennifer,Rogers, Catherine M.,Smith, Paul,Panagakou, Ioanna,Díaz-Sáez, Laura,Felce, Suet Ling,Gamble, Vicki,Gileadi, Carina,Halidi, Nadia,Heidenreich, David,Chaikuad, Apirat,Knapp, Stefan,Huber, Kilian V. M.,Farnie, Gillian,Heer, Jag,Manevski, Nenad,Poda, Gennady,Al-awar, Rima,Dixon, Darren J.,Brennan, Paul E.,Fedorov, Oleg

supporting information, p. 16302 - 16307 (2018/11/23)

YEATS domain (YD) containing proteins are an emerging class of epigenetic targets in drug discovery. Dysregulation of these modified lysine-binding proteins has been linked to the onset and progression of cancers. We herein report the discovery and characterisation of the first small-molecule chemical probe, SGC-iMLLT, for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). SGC-iMLLT is a potent and selective inhibitor of MLLT1/3–histone interactions. Excellent selectivity over other human YD proteins (YEATS2/4) and bromodomains was observed. Furthermore, our probe displays cellular target engagement of MLLT1 and MLLT3. The first small-molecule X-ray co-crystal structures with the MLLT1 YD are also reported. This first-in-class probe molecule can be used to understand MLLT1/3-associated biology and the therapeutic potential of small-molecule YD inhibitors.

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