181053-99-6Relevant academic research and scientific papers
Synthesis and antihistaminic H1 activity of 1,2,5(6)-trisubstituted benzimidazoles
Goeker, Hakan,Ayhan-Kilcigil, Guelguen,Tuncbilek, Meral,Kus, Canan,Ertan, Rahmiye,Kendi, Engin,Oezbey, Sueheyla,Fort, Merce,Garcia, Celia,Farre, Antonio J.
, p. 2561 - 2573 (2007/10/03)
A number of benzimidazoles, having several substituents on the azole and benzene nuclei and C-2 (methylamino, ethylenediamine, morpholine, piperazine and piperidine) were prepared. Regioselective synthesis was designed for the N1-alkyl substituted benzimidazoles (14-15). X-Ray structure analysis of (14) was also revealed. Compounds were evaluated for their in vitro H1- antihistaminic activity in the isolated guinea-pig ileum method. The compound (11) exhibits best activity.
Synthesis and antimicrobial activity of some new piperidinyl benzimidazoles
Kus,Goker,Ayhan,Ertan,Altanlar,Akin
, p. 413 - 417 (2007/10/03)
A series of 2-(4-methylpiperidin-1-yl)-1,5(6)-disubstituted-1H- benzimidazoles (1-18) were prepared through the reaction of 2-chloro (or 2- chloromethyl)-1H-benzimidazole derivatives with 4-methylpiperidine. For the preparation of the individual isomers,
