181073-30-3

Upstream product

• 14077-66-8 4-ethoxy-butyryl chloride 
• 164147-66-4 6-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one 

Downstream Products

• 181073-36-9 6-Benzyloxy-2-(4-ethoxy-1-methoxy-butyl)-3,4-dihydro-2H-isoquinolin-1-one 
• 181073-42-7 3-(6-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-ethoxy-hexanoic acid tert-butyl ester 

Relevant academic research and scientific papers

An acyliminium ion approach towards the synthesis of β-substituted 3,4-dihydroisoquinolone propionates

A variety of α-methoxy amides were prepared either by selective reduction of the exocyclic carbonyl of a 2-acyl-3,4-dihydroisoquinolone and subsequent trapping of the resultant α-hydroxy amide with acidic methanol or by reacting the sodium salt of 3,4-dihydroisoquinolone with a functionalized α-chloro ether. These intermediates were reacted with 1-tert-butoxy-1-tert-butyldimethylsiloxy ethene in the presence of BF3·Et2O providing access to β-substituted isoquinolone propionates in good yield.