181073-47-2

Upstream product

• 181073-35-8 6-Benzyloxy-2-butyryl-3,4-dihydro-2H-isoquinolin-1-one 
• 164147-66-4 6-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 74786-02-0 1-(tert-butyldimethylsilyloxy)-1-tert-butoxyethylene 

Downstream Products

• 181073-69-8 3-{6-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-hexanoic acid tert-butyl ester 
• 181073-62-1 3-[6-(4-Cyano-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-hexanoic acid tert-butyl ester 

Relevant academic research and scientific papers

An acyliminium ion approach towards the synthesis of β-substituted 3,4-dihydroisoquinolone propionates

A variety of α-methoxy amides were prepared either by selective reduction of the exocyclic carbonyl of a 2-acyl-3,4-dihydroisoquinolone and subsequent trapping of the resultant α-hydroxy amide with acidic methanol or by reacting the sodium salt of 3,4-dihydroisoquinolone with a functionalized α-chloro ether. These intermediates were reacted with 1-tert-butoxy-1-tert-butyldimethylsiloxy ethene in the presence of BF3·Et2O providing access to β-substituted isoquinolone propionates in good yield.