181073-64-3

Upstream product

• 181073-48-3 6-Ethoxy-3-(6-hydroxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-hexanoic acid tert-butyl ester 
• 181073-42-7 3-(6-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-ethoxy-hexanoic acid tert-butyl ester 
• 17201-43-3 4-cyanobenzyl bromide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 181073-57-4 3-[6-(4-Cyano-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-6-ethoxy-hexanoic acid tert-butyl ester 

Relevant academic research and scientific papers

Dihydroisoquinolone RGD mimics. Exploration of the aspartate isostere

Disubstituted 3,4-dihydroisoquinolones that contain an ether-linked benzamidine at C6 and a β-substituted aspartate mimic at C2 offer enhanced affinity for GPIIb-IIIa relative to the non-substituted isoquinolone propionate. Alkyl substituents afforded a 10-fold increase in intrinsic activity while aryl substituents yielded a 40-fold improvement.