18109-40-5Relevant academic research and scientific papers
Studies on organophosphorus compounds. XLV. Thiation of some sterically hindered N-nitrosamides
Joergensen, Karl Anker,Ghattas, Abdul-Badik,Lawesson, Sven-Olov
, p. 204 - 208 (2007/10/02)
Some sterically hindered N-nitrosamides have been prepared using sodium nitrite in aqueous acid solution.Reaction of these N-nitrosamides with 2,4-bis-(4-methoxyphenyl)-1,2,3,4-dithiadiphosphetane-2,4-disulfide (Lawesson's Reagent ) causes thiation of both the carbonyl and the nitroso groups followed by destruction of the nitroso group giving ultimately the corresponding thioamides and amides as the main products.Dihydro-2(3H)-thiophenone is isolated as a by-product when N-nitroso-dihydro-2(3H)-pyrrolidinone is reacted with LR.A mechanism for its formation is postulated.Thiation of the sterically hindered amides yields the thioamide as rotamers which in two cases could be separated by column chromatography.Ames test has been performed for some of the compounds.
