181122-00-9

Usage

Uses

Used in Pharmaceutical Industry:
4,4,6-TriMethyl-1,3-dihydroquinolin-2-one is used as a building block for the synthesis of various molecules with biological activity. Its unique chemical structure and properties make it a valuable component in the development of new pharmaceutical compounds.
Used in Agrochemical Industry:
In the agrochemical industry, 4,4,6-TriMethyl-1,3-dihydroquinolin-2-one serves as a precursor for the synthesis of molecules with pesticidal or herbicidal properties. Its potential applications in this field contribute to the development of more effective and environmentally friendly agrochemicals.
Used in Dye Production:
4,4,6-TriMethyl-1,3-dihydroquinolin-2-one is used as an intermediate in the production of dyes. Its chemical properties allow for the creation of dyes with specific characteristics, such as color intensity and stability.
Used in Specialty Chemicals:
4,4,6-TriMethyl-1,3-dihydroquinolin-2-one also has potential uses in the production of specialty chemicals, where its unique structure and properties can be leveraged to create novel compounds with specific applications in various industries.
Used in Organic Chemistry Research and Development:
Due to its unique chemical structure and properties, 4,4,6-TriMethyl-1,3-dihydroquinolin-2-one is an interesting target for research and development in the field of organic chemistry. It can provide insights into new synthetic pathways, reaction mechanisms, and potential applications in various chemical processes.

Upstream product

• 541-47-9 3-Methylbutenoic acid 
• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 106-49-0 p-toluidine 
• 21250-36-2 N-(4-methylphenyl)-3-methyl-2-butenamide 

Downstream Products

• 932367-35-6 3-[3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-qiuinolin-7-yl)-4-(2,2,2-trifluoro-ethoxy)-phenyl]-acrylic acid 
• 945039-08-7 3-[3-(1-Isopropyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-(2,2,2-trifluoro-ethoxy)-phenyl]-acrylic acid 
• 932367-99-2 C₂₈H₃₂F₃NO₄ 
• 932367-37-8 3-[3-(1,4,4,6-Tetramethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-trifluoromethoxy-phenyl]-acrylic acid 
• 932367-98-1 C₂₉H₃₄F₃NO₄ 
• 945039-13-4 C₂₉H₃₄F₃NO₄ 
• 945039-15-6 C₂₇H₃₀F₃NO₄ 
• 932367-36-7 3-[3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-qiuinolin-7-yl)-4-trifluoromethoxy-phenyl]-acrylic acid 
• 932367-38-9 3-[3-(1-Isopropyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)4-trifluoromethoxy-phenyl]-acrylic acid 
• 459811-04-2 3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-trifluoromethoxy-benzaldehyde 
• 945042-00-2 C₂₂H₂₂NO₃F₃ 
• 932367-95-8 3-(1-Ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-methoxy-benzaldehyde 
• 932367-97-0 3-(1-Ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-(2,2,2-trifluoro-ethoxy)-benzaldehyde 
• 932368-08-6 7-(5-Formyl-2-trifluoromethoxy-phenyl)-4,4,6-trimethyl-2-oxo-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR INHIBITION OF RENIN, AND INDICATIONS THEREFOR

Compounds active as inhibitors of renin are described, as well as methods of using such compounds to treat diseases and conditions associated with the renin-angiotensin system. Formula (I)

Aluminium chloride-catalyzed intermolecular vs intramolecular friedel-crafts reaction of acrylanilides and 3-chloropropanamides

3-Phenylpropionanilide (4a) is obtained in a yield of 89% from acrylanilide by the treatment with AlCl3/ benzene, compared with a yield of 39% by the 1,4-conjugate addition of phenyllithium. The formation of 4a indicated that an intermolecular Friedel-Crafts reaction occurred, rather than the relatively more facile intramolecular ring cyclization, and provided a more efficient route than a conjugate addition of phenyllithium for the preparation of 3-phenylpropionanilide and its derivatives. Although the methoxy group is an activator of the nucleophilic substitution, introduction of a methoxy substituent at N-phenyl did not increase the competitive capability of the intramolecular cyclization because of AlCl3-catalyzed demethylation to form the ArOAlCl2 complex which decreased the availability of the π-electron in the N-phenyl aromatic system.

FOTOQUIMICA DE -TOLUIDIDAS DE ACIDOS αβ-INSATURADOS. INFLUENCIA DE LA ADICION DE CARBONATO POTASICO

Irradiation of the p-toluidides of crotonic and cinnamic acids (2a,c) gives rise predominantly to the cis isomers 5a,c, together with appreciable amounts of 4,6-dimethyl-3,4-dihydro-2-quinolone (6a) in the case of 2a.The corresponding photo-Fries products have not been detected, even when the irradiation is performed in the presence of K2CO3.By contrast, photolysis of the p-toluidides of methylcrotonic and phenylpropiolic acids (2b,d) gives rise to the o-aminophenones 7b,d (in addition to the quinolone 6b from 2b).For these two amides, as well as for acetanilide and benzanilide, the selectivity towards the acyl migration product markedly increases when the irradiation is performed in the presence of K2CO3.Key words: Enamides' photocyclization, photo-Fries, quinolones.