18113-03-6

Basic information

• Product Name: 2-CHLORO-4-METHOXYPHENOL
• Synonyms: 3-CHLORO-4-HYDROXYANISOLE;2-CHLORO-4-METHOXYPHENOL;2-Chlorohydroquinonemonomethylether;2-chloro-4-methoxylphenol ;2-Chloro-4-methoxyphenol,97%;2-Chloro-4-Methoxyphenol, 97% 5GR;3-Chloro-4-hydroxyanisole, 2-Chloro-p-guaiacol
• CAS NO: 18113-03-6
• Molecular Formula: C₇H₇ClO₂
• Molecular Weight: 158.58
• EINECS: 242-007-3
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Phenol&Thiophenol&Mercaptan;Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds;Phenols;Organic Building Blocks;Oxygen Compounds;NULL
• Mol File: 18113-03-6.mol
• Article Data: 22

Chemical Properties

• Melting Point: 41-44 °C(lit.)
• Boiling Point: 241°C (rough estimate)
• Flash Point: 185 °F
• Appearance: White to light yellow/Crystalline Low Melting Solid
• Density: 1.153 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0184mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: 0-10°C
• PKA: 8.98±0.18(Predicted)
• BRN: 1936412
• CAS DataBase Reference: 2-CHLORO-4-METHOXYPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-METHOXYPHENOL(18113-03-6)
• EPA Substance Registry System: 2-CHLORO-4-METHOXYPHENOL(18113-03-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 18113-03-6(Hazardous Substances Data)

Usage

Chemical Properties

WHITE TO LIGHT YELLOW CRYST. LOW MELTING SOLID

InChI:InChI=1/C7H7ClO2/c1-10-5-2-3-7(9)6(8)4-5/h2-4,9H,1H3

Upstream product

• 1131890-97-5 2-chloro-4-methoxyphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 60672-33-5 4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 78646-39-6 2-(4-methoxyphenoxy)pyridine 
• 98-83-9 isopropenylbenzene 
• 1746-23-2 4-tert-Butylstyrene 
• 150-78-7 1,4-dimethoxybezene 
• 21306-21-8 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one 
• 150-76-5 4-methoxy-phenol 
• 108-95-2 phenol 
• 108534-51-6 4-((tert-butyldimethylsilyl)oxy)-4-methoxycyclohexa-2,5-dienone 
• 139139-72-3 4-methoxy-4-(prop-2-yn-1-yloxy)cyclohexa-2,5-dien-1-one 
• 73010-54-5 4-isopropoxy-4-methoxycyclohexa-2,5-dien-1-one 
• 73010-52-3 4-ethoxy-4-methoxycyclohexa-2,5-dien-1-one 

Downstream Products

• 708276-57-7 2-(2-chloro-4-methoxyphenoxy)-1-(4-methylsulfanylphenyl)ethanone 
• 869543-52-2 4-chloro-3-(2-chloro-4-methoxy-phenoxymethyl)-thieno[3,2-c]pyridine-7-carboxylic acid ethyl ester 
• 313655-08-2 2-(2-Chloro-4-methoxyphenoxy)ethyl 3-(1-piperazinyl)-2-pyrazinyl ether 
• 146949-17-9 1,1'-[1,6-hexanediyl bis(oxy)]bis-[2-chloro-4-methoxybenzene] 
• 935692-85-6 [2-(2-chloro-4-methoxy-phenoxy)-ethyl]-diethyl-amine 
• 1262210-25-2 4-(2-chloro-4-methoxyphenyl)-3,6-dihydro-2H-pyran 
• 1262210-28-5 2'-chloro-2,4'-dimethoxy-2,3,4,5-tetrahydro-1,1'-biphenyl 
• 1262210-20-7 2-chloro-4-methoxy-1-(1-(p-tolyl)vinyl)benzene 
• 1262210-31-0 (Z)-2-chloro-4-methoxy-1-(1-(4-methoxyphenyl)prop-1-en-1-yl)benzene 
• 1262210-34-3 (Z)-(1-(2-chloro-4-methoxyphenyl)ethene-1,2-diyl)dibenzene 
• 1262210-21-8 2-chloro-4-methoxy-1-(1-(4-methoxyphenyl)vinyl)benzene 
• 1262210-22-9 4-(1-(2-chloro-4-methoxyphenyl)vinyl)benzonitrile 
• 150-76-5 4-methoxy-phenol 
• 37603-26-2 2-(hydroxymethyl)-5-methoxy-benzo[b]furan 

Relevant articles and documents

Unprecedented Regioregular Poly(1,4-arylene)s Prepared by Nickel(II)-Catalyzed Cross-Coupling Polymerization of 2,5-Disubstituted Bromo(chloro)arylene

The unprecedented synthesis of regioregular head-to-tail-type poly(1,4-arylene)s bearing different substituents at the 2- and 5-positions is described. They were prepared by the polymerization of 2,5-disubstituted bromo(chloro)arylenes by selective halogen–metal exchange with a Grignard reagent and subsequent cross-coupling polymerization with a nickel catalyst [NiCl2(dppp)]. Formation of the regioregular poly(1,4-arylene)s were confirmed by NMR spectroscopy, and showed remarkable differences to those polymers having uncontrolled regioregularity. Polymerization of bromo(chloro)arylenes with a chiral alkoxy substituent also led to the regioregular head-to-tail-type polyarylene, which demonstrated circular dichroism, thus suggesting formation of a structure with higher-order regularity.

Para -Selective hydroxylation of alkyl aryl ethers

para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(ii) catalyst, hypervalent iodine(iii) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clinical drugs monobenzone and pramocaine on a gram scale.

Regioselective synthesis of gentisyl alcohol-type marine natural products

Gentisyl alcohol-type natural products, possessing various important biological properties, have been synthesized from 4-methoxyphenol by using a selective phenol monohydroxymethylation/monochlorination, a CAN oxidation and a sodium dithionite reduction as the key steps. The natural product synthesis is efficient, atom- and step-economical, and requires no protecting groups.