181148-01-6

Basic information

• Product Name: 4-MALEIMIDOBUTYRIC ACID HYDRAZIDE
• Synonyms: 4-MALEIMIDOBUTYRIC ACID HYDRAZIDE;4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanehydrazide;2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-butanoic acid hydrazide;4-MaleiMidobutyric acid htdrazide
• CAS NO: 181148-01-6
• Molecular Formula: C8H11N3O3
• Molecular Weight: 197.2
• Mol File: 181148-01-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 472.232 °C at 760 mmHg
• Flash Point: 239.398 °C
• Appearance: /
• Density: 1.348±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• PKA: 13.12±0.35(Predicted)
• CAS DataBase Reference: 4-MALEIMIDOBUTYRIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MALEIMIDOBUTYRIC ACID HYDRAZIDE(181148-01-6)
• EPA Substance Registry System: 4-MALEIMIDOBUTYRIC ACID HYDRAZIDE(181148-01-6)

Safety Data

• Hazardous Substances Data: 181148-01-6(Hazardous Substances Data)

Usage

General Description

4-Maleimidobutyric acid hydrazide is a chemical compound that is used in the field of bioconjugation and crosslinking. It contains a maleimide group that can react with thiol-containing molecules, making it useful in the modification of proteins, peptides, and other biomolecules. 4-MALEIMIDOBUTYRIC ACID HYDRAZIDE is often used in the creation of antibody-drug conjugates, as well as in the development of drug delivery systems and biomaterials. Its unique reactivity and stability make it a valuable tool for researchers and scientists working in the fields of biochemistry, biotechnology, and pharmaceuticals.

Upstream product

• 1239587-67-7 tert-butyl 2-(4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoyl)hydrazinecarboxylate 
• 116965-29-8 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoyl chloride 
• 57078-98-5 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid 

Relevant articles and documents

Preparation method of heterobifunctional protein cross-linking agent having hydrazide structure

The invention relates to the technical field of preparation of compounds, in particular to a preparation method of a heterobifunctional protein cross-linking agent having a hydrazide structure. The method comprises the following steps: enabling maleimide alkyl acid, i.e., a compound A to be subjected to a heating reaction under the action of a solvent and sulfoxide chloride so as to enable a carboxyl group in the structure of the compound A to be converted into acyl chloride; mixing obtained maleimide alkyl acyl chloride with a solvent and various types of compounds B, and performing an acylation reaction under the action of organic or inorganic alkali so as to generate a compound C; and removing a protecting group at the hydrazine end of the compound C under the action of a solvent and acid or alkali so as to obtain maleimide alkyl hydrazide having the hydrazide structure. According to the method involved in the invention, the cheap and readily available maleimide alkyl acid, as a starting raw material, is prepared into the maleimide alkyl hydrazide by three steps of reactions; the yield of a synthetic route is higher; a product is suitable for the research and development and production of an antibody-drug conjugate; and a synthesis method is simple and convenient to operate, safe and controllable, and suitable for industrial production.